[HTML][HTML] Contribution of neurons and glial cells to complement-mediated synapse removal during development, aging and in Alzheimer's disease
C Luchena, J Zuazo-Ibarra, E Alberdi… - Mediators of …, 2018 - hindawi.com
Synapse loss is an early manifestation of pathology in Alzheimer’s disease (AD) and is
currently the best correlate to cognitive decline. Microglial cells are involved in synapse pruning …
currently the best correlate to cognitive decline. Microglial cells are involved in synapse pruning …
[HTML][HTML] Amyloid β/PKC-dependent alterations in NMDA receptor composition are detected in early stages of Alzheimer´ s disease
…, T Quintela-López, A Ruiz, C Luchena… - Cell Death & …, 2022 - nature.com
Amyloid beta (Aβ)-mediated synapse dysfunction is an early event in Alzheimer’s disease (AD)
pathogenesis and previous studies suggest that NMDA receptor (NMDAR) dysregulation …
pathogenesis and previous studies suggest that NMDA receptor (NMDAR) dysregulation …
[HTML][HTML] A neuron, microglia, and astrocyte triple co-culture model to study Alzheimer's disease
C Luchena, J Zuazo-Ibarra, J Valero… - Frontiers in Aging …, 2022 - frontiersin.org
Glial cells are essential to understand Alzheimer’s disease (AD) progression, given their
role in neuroinflammation and neurodegeneration. There is a need for reliable and easy to …
role in neuroinflammation and neurodegeneration. There is a need for reliable and easy to …
[HTML][HTML] A nonlinear meccano for Alzheimer's emergence by amyloid β-mediated glutamatergic hyperactivity
G Bonifazi, C Luchena, A Gaminde-Blasco… - Neurobiology of …, 2024 - Elsevier
The pathophysiological process of Alzheimer's disease (AD) is believed to begin many
years before the formal diagnosis of AD dementia. This protracted preclinical phase offers a …
years before the formal diagnosis of AD dementia. This protracted preclinical phase offers a …
[HTML][HTML] Sephin1 protects neurons against excitotoxicity independently of the integrated stress response
A Ruiz, J Zuazo, C Ortiz-Sanz, C Luchena… - International journal of …, 2020 - mdpi.com
Sephin1 is a derivative of guanabenz that inhibits the dephosphorylation of the eukaryotic
initiation factor 2 alpha (eIF2α) and therefore may enhance the integrated stress response (ISR…
initiation factor 2 alpha (eIF2α) and therefore may enhance the integrated stress response (ISR…
Corrigendum to “Contribution of neurons and glial cells to complement-mediated synapse removal during development, aging and in Alzheimer's disease”
C Luchena, J Zuazo-Ibarra, E Alberdi… - Mediators of …, 2019 - hindawi.com
… Copyright © 2019 Celia Luchena et al. This is an open access article distributed under the
… Jone Zuazo held a fellowship from Gobierno Vasco, and Celia Luchena from Fundación …
… Jone Zuazo held a fellowship from Gobierno Vasco, and Celia Luchena from Fundación …
The nonlinear meccano of hyperactivity in Alzheimer
G Bonifazi, C Luchena, A Gaminde-Blasco… - bioRxiv, 2023 - biorxiv.org
The pathophysiological process of Alzheimer's disease (AD) is believed to begin many
years before the formal diagnosis of AD dementia. This protracted preclinical phase offers a …
years before the formal diagnosis of AD dementia. This protracted preclinical phase offers a …
A Neuron, Microglia, and Astrocyte Triple Co-culture Model to Study Alzheimer's Disease
C Luchena Moreno, J Zuazo Ibarra… - 2022 - addi.ehu.es
Glial cells are essential to understand Alzheimer's disease (AD) progression, given their
role in neuroinflammation and neurodegeneration. There is a need for reliable and easy to …
role in neuroinflammation and neurodegeneration. There is a need for reliable and easy to …
Aβ Oligomers Alter NMDA Receptor Composition and Function in Early Stages of Alzheimer´ s Disease
…, T Quintela-López, A Ruiz, U Balantzategi, C Luchena… - 2021 - researchsquare.com
Background Amyloid beta (Aβ)-mediated synapse dysfunction is an early event in
Alzheimer's disease (AD) pathogenesis and previous studies suggest that NMDA receptor (NMDAR) …
Alzheimer's disease (AD) pathogenesis and previous studies suggest that NMDA receptor (NMDAR) …
Sephin1 Protects Neurons against Excitotoxicity Independently of the Integrated Stress Response
…, J Zuazo Ibarra, C Ortiz Sanz, C Luchena Moreno… - 2020 - addi.ehu.es
Sephin1 is a derivative of guanabenz that inhibits the dephosphorylation of the eukaryotic
initiation factor 2 alpha (eIF2α) and therefore may enhance the integrated stress response (ISR…
initiation factor 2 alpha (eIF2α) and therefore may enhance the integrated stress response (ISR…