Background Photodynamic therapy (PDT) is approved for treatment of actinic keratoses (AKs)
and field-cancerisation. Pretreatment with pharmacological compounds holds potential to …

Simple Summary Keratinocyte carcinoma is the most common type of cancer. Sun exposure
and ultraviolet radiation are significant contributors to the development of carcinogenesis, …

Although endoplasmic reticulum (ER) chaperone binding to mutant proinsulin has been
reported, the role of protein chaperones in the handling of wild-type proinsulin is …

Ultraviolet radiation is the primary risk factor for keratinocyte carcinoma. Because of increasing
incidence rates, new methods of photoprotection must be explored. Oral supplementation …

A central and still open question regarding the pathogenesis of autoimmune diseases, such
as type 1 diabetes, concerns the processes that underlie the generation of MHC-presented …

Proinsulin is a misfolding-prone protein, and its efficient breakdown is critical when β-cells
are confronted with high-insulin biosynthetic demands, to prevent endoplasmic reticulum …

Background: Phytochemicals have demonstrated great potential as photoprotectants. Apple-derived
compounds such as quercetin, fisetin, and rutin are reported to provide topical …

Squamous cell carcinoma represents the second most common type of keratinocyte carcinoma
with ultraviolet radiation (UVR) making up the primary risk factor. Oral photoprotection …

Apart from chaperoning, disulfide bond formation, and downstream processing, the molecular
sequence of proinsulin folding is not completely understood. Proinsulin requires proline …

Pancreatic β-cells, residents of the islets of Langerhans, are the unique insulin-producers in
the body. Their physiology is a topic of intensive studies aiming to understand the biology of …