Induction of Dormancy in Arabidopsis Summer Annuals Requires Parallel Regulation of DOG1 and Hormone Metabolism by Low Temperature and CBF …

SL Kendall, A Hellwege, P Marriot, C Whalley… - The Plant …, 2011 - academic.oup.com
Summer annuals overwinter as seeds in the soil seed bank. This is facilitated by a cold-induced
increase in dormancy during seed maturation followed by a switch to a state during seed …

SARS-CoV-2 seroprevalence and asymptomatic viral carriage in healthcare workers: a cross-sectional study

…, EM Walker, K Wanigasooriya, Y Watanabe, C Whalley… - Thorax, 2020 - thorax.bmj.com
Objective To determine the rates of asymptomatic viral carriage and seroprevalence of
SARS-CoV-2 antibodies in healthcare workers. Design A cross-sectional study of asymptomatic …

Image-based consensus molecular subtype (imCMS) classification of colorectal cancer using deep learning

…, SJ Leedham, A Chatzipli, C Hardy, CM Whalley… - Gut, 2021 - gut.bmj.com
Objective Complex phenotypes captured on histological slides represent the biological
processes at play in individual cancers, but the link to underlying molecular classification has not …

Ultrarapid detection of SARS-CoV-2 RNA using a reverse transcription–free exponential amplification reaction, RTF-EXPAR

…, CD Southern, M Rana, CM Whalley… - Proceedings of the …, 2021 - National Acad Sciences
A rapid isothermal method for detecting severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2),
the virus responsible for COVID-19, is reported. The procedure uses an …

[PDF][PDF] Germline MBD4 deficiency causes a multi-tumor predisposition syndrome

…, C Turnbull, L Vreede, T van Wezel, C Whalley… - The American Journal of …, 2022 - cell.com
We report an autosomal recessive, multi-organ tumor predisposition syndrome, caused by bi-allelic
loss-of-function germline variants in the base excision repair (BER) gene MBD4. We …

SARS-CoV-2 seroconversion in health care workers

…, E Walker, K Wanigasooriya, Y Watanabe, C Whalley… - MedRxiv, 2020 - medrxiv.org
Background The correlates of protection against SARS-CoV-2 and their longevity remain
unclear. Studies in severely ill individuals have identified robust cellular and humoral immune …

[HTML][HTML] Diagnostic accuracy of loop-mediated isothermal amplification coupled to nanopore sequencing (LamPORE) for the detection of SARS-CoV-2 infection at …

A Ptasinska, C Whalley, A Bosworth, C Poxon… - Clinical microbiology …, 2021 - Elsevier
Objectives Rapid, high throughput diagnostics are a valuable tool, allowing the detection of
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in populations so as to …

[PDF][PDF] The miR-430 locus with extreme promoter density forms a transcription body during the minor wave of zygotic genome activation

…, L Wheatley, L Cooper, F Ansaloni, C Whalley… - Developmental cell, 2023 - cell.com
In anamniote embryos, the major wave of zygotic genome activation starts during the mid-blastula
transition. However, some genes escape global genome repression, are activated …

Targeted deep sequencing of urothelial bladder cancers and associated urinary DNA: a 23‐gene panel with utility for non‐invasive diagnosis and risk stratification

…, L Baxter, S Ott, L Silcock, CM Whalley… - BJU …, 2019 - Wiley Online Library
Objectives To develop a focused panel of somatic mutations ( SM s) present in the majority
of urothelial bladder cancers ( UBC s), to investigate the diagnostic and prognostic utility of …

Engineering amino acid uptake or catabolism promotes CAR T-cell adaption to the tumor environment

…, C Smith, A Vardon, L Vettore, C Whalley… - Blood …, 2023 - ashpublications.org
Cancer cells take up amino acids from the extracellular space to drive cell proliferation and
viability. Similar mechanisms are applied by immune cells, resulting in the competition …