Systems analysis of RhoGEF and RhoGAP regulatory proteins reveals spatially organized RAC1 signalling from integrin adhesions

…, J Rademacher, RD Bagshaw, C Wortmann… - Nature cell …, 2020 - nature.com
Rho GTPases are central regulators of the cytoskeleton and, in humans, are controlled by
145 multidomain guanine nucleotide exchange factors (RhoGEFs) and GTPase-activating …

[PDF][PDF] Direct observation of cell-cycle-dependent interactions between CTCF and chromatin

H Agarwal, M Reisser, C Wortmann, JCM Gebhardt - Biophysical journal, 2017 - cell.com
The three-dimensional arrangement of chromatin encodes regulatory traits important for
nuclear processes such as transcription and replication. Chromatin topology is in part mediated …

Spatial organization of Rho GTPase signaling by RhoGEF/RhoGAP proteins

…, G Mbamalu, M Tucholska, L Spatt, C Wortmann… - Biorxiv, 2018 - biorxiv.org
Rho GTPases control cell shape formation and thus fundamental physiological processes in
all eukaryotes. Their functions are regulated by 145 RhoGEF and RhoGAP multi-domain …

[PDF][PDF] Perm-waved human hair: a thermorheologically complex shape memory composite

FJ Wortmann, C Jones, TJ Davies, G Wortmann - Biophysical Journal, 2021 - cell.com
A "permanent" bent shape can be imposed on a straight human hair by a two-stage
reduction/oxidation (perm-waving) process. The process relies on the molecular level on sulfhydryl/…

[HTML][HTML] pH-equilibration of human hair: Kinetics and pH-dependence of the partition ratios for H+− and OH−-ions based on a Freundlich isotherm

FJ Wortmann, K Hardie, N Schellenberg, C Jones… - Biophysical …, 2023 - Elsevier
Hair is an insoluble, fibrous, α-keratinous, protein composite material, providing outer
coverage, eg, for mammals. In the context of a wider study on the effects of pH on human hair …

Neutropenia and intellectual disability are hallmarks of biallelic and de novo CLPB deficiency

SB Wortmann, S Ziętkiewicz, S Guerrero-Castillo… - Genetics in …, 2021 - nature.com
Purpose To investigate monoallelic CLPB variants. Pathogenic variants in many genes cause
congenital neutropenia. While most patients exhibit isolated hematological involvement, …

[HTML][HTML] Textile materials inspired by structural colour in nature

C Jones, FJ Wortmann, HF Gleeson, SG Yeates - RSC advances, 2020 - pubs.rsc.org
The concept of mimicking structural colour in nature as an alternative to traditional textile
coloration techniques would reduce dependency on dyes, pigments and vast quantities of …

The Effects of Humidity on Hairstyles: Analysis of the mechanical properties of styling polymers

…, G Wortmann, FJ Wortmann - Proc 22nd …, 2021 - research.manchester.ac.uk
The aim of this study is to extend the knowledge gained through the dynamic humidity curl
retention (DHCR) to determine the influence of the polymers in the composite (polymer/hair) …

High-strain stress relaxation: probing the main structural components in the cortex of human hair

…, G Wortmann, C Jones, K Lee, FJ Wortmann - 2021 - e-space.mmu.ac.uk
The relation between the main cortical structures in hair (IFs & matrix) and its mechanical
properties has been studied for many years. Beyond fundamentals aspects, this was also done …

Liquid Crystals Science and Technology: Editor's Themed Collection

C Jones, FJ Wortmann, H Gleeson, S Yates - 2022 - research.manchester.ac.uk
Welcome to this themed collection on “Liquid Crystals Science and Technology”, guest
edited by Dr Giacomo Saielli (Italian National Research Council and University of Padova).