During carcinogenesis, almost all the biological processes are modified in one way or another.
Among these biological processes affected, anomalies in protein synthesis are common …

The unfolded protein response (UPR) is an evolutionarily conserved adaptive signaling
pathway triggered by a stress of the endoplasmic reticulum (ER) lumen compartment, which is …

Resistance to standard and novel therapies remains the main obstacle to cure in acute myeloid
leukaemia (AML) and is often driven by metabolic adaptations which are therapeutically …

Myelodysplastic syndromes (MDS) are hematopoietic stem cell (HSC) malignancies characterized
by ineffective hematopoiesis, with increased incidence in older individuals. Here we …

Angiogenesis is induced by various conditions, including hypoxia. Although cap-dependent
translation is globally inhibited during ischemia, the mRNAs encoding two important …

Background. In contrast to multiple rare monogenetic abnormalities, a common biomarker
among children with infantile autism and their parents is the discovery of serum …

Dysregulated expression of translation initiation factors has been associated with carcinogenesis,
but underlying mechanisms remains to be fully understood. Here we show that eIF4H (…

Patients with myelodysplastic syndrome and ring sideroblasts (MDS-RS) present with
symptomatic anemia due to ineffective erythropoiesis that impedes their quality of life and …

Under physiological stress conditions the cell protects itself through a global blockade on
cap-dependent translation of mRNA. This allows cap-independent mechanisms such as …

Despite the inclusion of inherited myeloid malignancies as a separate entity in the World
Health Organization Classification, many established predisposing loci continue to lack …