Cellular mechanisms governing redox homeostasis likely involve their integration with other
stresses. Endoplasmic reticulum (ER) stress triggers complex adaptive or proapoptotic …

The heart has complex mechanisms that facilitate the maintenance of an oxygen supply–demand
balance necessary for its contractile function in response to physiological fluctuations …

Significance: Reactive oxygen species (ROS) are produced during normal endoplasmic
reticulum (ER) metabolism. There is accumulating evidence showing that under stress …

Cardiac failure occurs when the heart fails to adapt to chronic stresses. Reactive oxygen
species (ROS)-dependent signaling is implicated in cardiac stress responses, but the role of …

Uric acid has been considered to be an efficient scavenger of peroxynitrite but the reaction
between urate and peroxynitrite has been only partially characterized. Also, previous studies …

NAD(P)H oxidase, the main source of reactive oxygen species in vascular cells, is known to
be regulated by redox processes and thiols. However, the nature of thiol-dependent …

Reactive oxygen species (ROS) contribute to tissue damage and remodelling mediated by
the inflammatory response after injury. Here we show that ROS, which promote axonal …

Dihydroethidium (DHE) is a widely used sensitive superoxide (O 2 •− ) probe. However, DHE
oxidation yields at least two fluorescent products, 2-hydroxyethidium (EOH), known to be …

Background: The adult mammalian heart has limited regenerative capacity, mostly attributable
to postnatal cardiomyocyte cell cycle arrest. In the last 2 decades, numerous studies have …

It is increasingly evident that redox-dependent modifications in cellular proteins and signaling
pathways (or redox signaling) play important roles in many aspects of cardiac hypertrophy. …