Basal forebrain cholinergic neurons (BFCNs) are believed to be one of the first cell types to
be affected in all forms of AD, and their dysfunction is clinically correlated with impaired short-…

Although ACE2 is the primary receptor for Severe Acute Respiratory Syndrome Coronavirus
2 (SARS-CoV-2) infection, a systematic assessment of host factors that regulate binding to …

Background Type 2 diabetes (T2D) is a recognized risk factor for the development of cognitive
impairment (CI) and/or dementia, although the exact nature of the molecular pathology of …

Aging constitutes the central risk factor for major diseases including many forms of cancer,
neurodegeneration, and cardiovascular diseases. The aging process is characterized by both …

We propose that energy balance, glucose homeostasis, and aging are all regulated largely
by the same nutrient-sensing neurons in the ventromedial hypothalamus (VMH). Although …

Huntington's disease (HD) is a fatal neurodegenerative disease characterized by metabolic,
cognitive, and motor deficits. HD is caused by an expanded CAG repeat in the first exon of …

Dietary restriction (DR) can extend lifespan and reduce disease burden across a wide range
of animals and yeast but the mechanisms mediating these remarkably protective effects …

Although ACE2 is the primary receptor for SARS-CoV-2 infection, a systematic assessment
of factors controlling SARS-CoV-2 host interactions has not been described. Here we used …

Background Widescale evidence points to the involvement of glia and immune pathways in
the progression of Alzheimer’s disease (AD). AD-associated iPSC-derived glial cells show a …

We have reported a correlation between hypothalamic expression of Creb-binding protein (Cbp)
and lifespan, and that inhibition of Cbp prevents protective effects of dietary restriction …