Pseudomonas aeruginosa: all roads lead to resistance

EBM Breidenstein, C de la Fuente-Núñez… - Trends in …, 2011 - cell.com
Pseudomonas aeruginosa is often resistant to multiple antibiotics and consequently has
joined the ranks of ‘superbugs' due to its enormous capacity to engender resistance. It …

The value of antimicrobial peptides in the age of resistance

…, C Pinilla, C de La Fuente-Nunez… - The lancet infectious …, 2020 - thelancet.com
Accelerating growth and global expansion of antimicrobial resistance has deepened the need
for discovery of novel antimicrobial agents. Antimicrobial peptides have clear advantages …

Bacterial biofilm development as a multicellular adaptation: antibiotic resistance and new therapeutic strategies

C De la Fuente-Núñez, F Reffuveille… - Current opinion in …, 2013 - Elsevier
… Author links open overlay panel César de la Fuente-Núñez , Fany Reffuveille , Lucía
Fernández , Robert EW Hancock … de la Fuente-Núñez, REW Hancock …

[HTML][HTML] Broad-spectrum anti-biofilm peptide that targets a cellular stress response

C De la Fuente-Núñez, F Reffuveille, EF Haney… - PLoS …, 2014 - journals.plos.org
Bacteria form multicellular communities known as biofilms that cause two thirds of all
infections and demonstrate a 10 to 1000 fold increase in adaptive resistance to conventional …

Leveraging artificial intelligence in the fight against infectious diseases

F Wong, C de la Fuente-Nunez, JJ Collins - Science, 2023 - science.org
Despite advances in molecular biology, genetics, computation, and medicinal chemistry,
infectious disease remains an ominous threat to public health. Addressing the challenges …

Next-generation precision antimicrobials: towards personalized treatment of infectious diseases

C de la Fuente-Nunez, MDT Torres, FJM Mojica… - Current opinion in …, 2017 - Elsevier
Highlights • Precision antimicrobials represent a novel approach for treating infectious
diseases. • The role of the microbiota in health and disease is indisputable and so is the need to …

[PDF][PDF] D-enantiomeric peptides that eradicate wild-type and multidrug-resistant biofilms and protect against lethal Pseudomonas aeruginosa infections

C De La Fuente-Núñez, F Reffuveille, SC Mansour… - Chemistry & biology, 2015 - cell.com
In many infections, bacteria form surface-associated communities known as biofilms that are
substantially more resistant to antibiotics than their planktonic counterparts. Based on the …

Development of molecularly imprinted polymers to block quorum sensing and inhibit bacterial biofilm formation

L Ma, S Feng, C Fuente-Núñez… - … applied materials & …, 2018 - ACS Publications
Bacterial biofilms are responsible for most clinical infections and show increased antimicrobial
resistance. In this study, molecularly imprinted polymers (MIPs) were developed to …

A broad-spectrum antibiofilm peptide enhances antibiotic action against bacterial biofilms

F Reffuveille, C De La Fuente-Nú̃nez… - Antimicrobial agents …, 2014 - Am Soc Microbiol
Biofilm-related infections account for at least 65% of all human infections, but there are no
available antimicrobials that specifically target biofilms. Their elimination by available …

3D printing of living responsive materials and devices

…, TC Tang, E Tham, C de la FuenteNunez… - Advanced …, 2018 - Wiley Online Library
3D printing has been intensively explored to fabricate customized structures of responsive
materials including hydrogels, liquid‐crystal elastomers, shape‐memory polymers, and …