Isothermal titration calorimetry (ITC) is a powerful classical method that enables researchers
in many fields to study the thermodynamics of molecular interactions. Primary ITC data …

The analysis of analytical ultracentrifugation (AUC) data has been greatly facilitated by the
advances accumulated in recent years. These improvements include refinements in AUC-…

New levels in the understanding of DNA replication have been achieved from recent crystal
structure determinations of several DNA polymerases and their substrate complexes. The …

RIG-I and MDA5 detect viral RNA in the cytoplasm and activate signaling cascades leading
to the production of type-I interferons. RIG-I is activated through sequential binding of viral …

The presence of DNA in the cytoplasm is a danger signal that triggers immune and inflammatory
responses. Cytosolic DNA binds to and activates cyclic GMP-AMP (cGAMP) synthase (…

Signals generated by cryptochrome (CRY) blue-light photoreceptors are responsible for a
variety of developmental and circadian responses in plants. The CRYs are also identified as …

Misfolding of ΔF508 cystic fibrosis (CF) transmembrane conductance regulator (CFTR)
underlies pathology in most CF patients. F508 resides in the first nucleotide-binding domain (…

Isothermal titration calorimetry (ITC) is a powerful and widely used method to measure the
energetics of macromolecular interactions by recording a thermogram of differential heating …

Stu2p/XMAP215/Dis1 family proteins are evolutionarily conserved regulatory factors that
use αβ-tubulin–interacting tumor overexpressed gene (TOG) domains to catalyze fast …

Actin related protein 2/actin related protein 3 (Arp2/3) complex nucleates new actin filaments
in eukaryotic cells in response to signals from proteins in the Wiskott–Aldrich syndrome …