Extracellular interaction between programmed death ligand-1 (PD-L1) and programmed cell
death protein-1 (PD-1) leads to tumour-associated immune escape. Here we show that the …

Pro-inflammatory cytokines produced in the tumor microenvironment lead to eradication of
anti-tumor immunity and enhanced tumor cell survival. In the current study, we identified …

The engagement of programmed cell death protein 1 (PD-1; encoded by the PDCD1 gene)
receptor expressed on activated T cells and its ligand, programmed death-ligand 1 (PD-L1; …

Metformin has been reported to possess antitumor activity and maintain high cytotoxic T
lymphocyte (CTL) immune surveillance. However, the functions and detailed mechanisms of …

Mutations in isocitrate dehydrogenase 1 (IDH1) and isocitrate dehydrogenase 2 (IDH2)
occur in most grade 2 and 3 gliomas, secondary glioblastomas, and a subset of acute …

We examine the relation between internal control quality and the accuracy of management
guidance. Consistent with managers in firms with ineffective internal controls relying on …

THE majority ( ∼ 75%) of infant acute leukaemias have a reciprocal translocation between
chromosome 11q23 and one of several partner chromosomes 1 . The gene at 1lq23 (named …

Protein glycosylation provides proteomic diversity in regulating protein localization, stability,
and activity; it remains largely unknown whether the sugar moiety contributes to …

Dear Editor, The tumor-microenvironment interactions play important roles in tumor progression,
metastasis, and therapeutic resistance, 1 and increasing evidence indicates that tumor …

This study analyzes the impact of internal control quality on audit delay following the
implementation of the Sarbanes‐Oxley Act (2002) (SOX). Unlike prior studies of audit delay that …