Chronic inflammation triggers compensatory immunosuppression to stop inflammation and
minimize tissue damage. Studies have demonstrated that endoplasmic reticulum (ER) stress …

Background TET enzymes mediate DNA demethylation by oxidizing 5-methylcytosine (5mC)
in DNA to 5-hydroxymethylcytosine (5hmC), 5-formylcytosine (5fC), and 5-carboxylcytosine (…

Ascorbate (vitamin C) is an essential micronutrient in humans. The severe chronic deficiency
of ascorbate, termed scurvy, has long been associated with increased susceptibility to …

Metabolites are the essential substrates for epigenetic modification enzymes to write or erase
the epigenetic blueprint in cells. Hence, the availability of nutrients and activity of metabolic …

Cell identity and function largely rely on the programming of transcriptomes during development
and differentiation. Signature gene expression programs are orchestrated by regulatory …

Micronutrients are essential small molecules required by organisms in minute quantity for
survival. For instance, vitamins and minerals, the two major categories of micronutrients, are …

Sequence motif discovery algorithms enhance the identification of novel deoxyribonucleic
acid sequences with pivotal biological significance, especially transcription factor (TF)-binding …

1 T follicular helper cells (Tfh) are a specialized Th cell subset whose primary function is to
activate B cells to promote the generation of high-affinity Abs and long-lasting humoral …

TET2 loss in erythroleukemia cells induces hypermethylation and impaired expression of
erythroid differentiation genes which can be specifically counteracted by 5-Azacytidine, …

Ascorbate (vitamin C) is an essential micronutrient in humans. The chronic severe deficiency
of ascorbate, termed scurvy, has long been associated with increased susceptibility to …