Longitudinal dynamics of the neutralizing antibody response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection

…, J Hu, QZ Gao, GJ Zhang, CL He… - Clinical Infectious …, 2021 - academic.oup.com
Background Coronavirus disease 2019 (COVID-19) is a global pandemic with no licensed
vaccine or specific antiviral agents for therapy. Little is known about the longitudinal dynamics …

D614G mutation of SARS-CoV-2 spike protein enhances viral infectivity

J Hu, CL He, QZ Gao, GJ Zhang, XX Cao, QX Long… - BioRxiv, 2020 - biorxiv.org
Coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2). The spike (S) protein that mediates SARS-CoV-2 entry into host …

A peptide-based magnetic chemiluminescence enzyme immunoassay for serological diagnosis of coronavirus disease 2019

…, C Gan, Y Chen, Q Gao, A Chen, C He… - The Journal of …, 2020 - academic.oup.com
Background Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a novel β-coronavirus,
causes severe pneumonia and has spread throughout the globe rapidly. The …

[HTML][HTML] Identification of bis-benzylisoquinoline alkaloids as SARS-CoV-2 entry inhibitors from a library of natural products

CL He, LY Huang, K Wang, CJ Gu, J Hu… - Signal transduction and …, 2021 - nature.com
Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus
2 (SARS-CoV-2) is a major public health issue. The spike (S) protein mutation D614G …

[HTML][HTML] Ferulic Acid Exerts Neuroprotective Effects via Autophagy Induction in C. elegans and Cellular Models of Parkinson's Disease

T Long, Q Wu, J Wei, Y Tang, YN He, CL He… - … medicine and cellular …, 2022 - hindawi.com
Parkinson’s disease (PD) is a complex neurological disorder characterized by motor and
nonmotor features. Although some drugs have been developed for the therapy of PD in a …

Chlorogenic acid delays the progression of Parkinson's disease via autophagy induction in Caenorhabditis elegans

CL He, Y Tang, JM Wu, T Long, L Yu… - Nutritional …, 2023 - Taylor & Francis
Objectives Parkinson’s disease (PD) is the second most common neurodegenerative
disease. Chlorogenic acid (CGA) is a polyphenolic substance derived from various medicinal …

Folium Hibisci Mutabilis extract, a potent autophagy enhancer, exhibits neuroprotective properties in multiple models of neurodegenerative diseases

CL He, Y Tang, X Chen, T Long, YN He, J Wei, JM Wu… - Phytomedicine, 2023 - Elsevier
… Thus, we continued to check neuronal health using HE and Nissl staining methods. The
HE staining images showed substantial neuronal loss in the CA2 and CA3 regions of 3 × Tg-AD …

Citri Reticulatae Semen Extract Promotes Healthy Aging and Neuroprotection via Autophagy Induction in Caenorhabditis elegans

T Long, Y Tang, YN He, CL He, X Chen… - The Journals of …, 2022 - academic.oup.com
Nutrition intervention has emerged as a potential strategy to delay aging and promote healthy
longevity. Citri Reticulatae Semen (CRS) has diverse beneficial effects and has been used …

[HTML][HTML] Targeting autophagy as a therapeutic strategy for identification of liganans from Peristrophe japonica in Parkinson's disease

…, R Pan, BYK Law, WQ Qiu, JM Wu, CL He… - Signal transduction and …, 2021 - nature.com
PD is characterized by the loss of dopaminergic neurons in substantia nigra, and the loss of
dopamine resulting in motor deficit. 1 Its main pathological hallmarks include the genetic …

[HTML][HTML] Two 18‐norspirostane steroidal saponins as novel mitophagy enhancers improve Alzheimer's disease

WQ Qiu, L Yu, CL He, JM Wu, BYK Law… - Clinical and …, 2023 - ncbi.nlm.nih.gov
Dear Editor, The hallmark of Alzheimer’s disease (AD) is the progressive accumulation of
misfolded proteins, specifically beta-amyloid (Aβ) and Tau, leading to neurotoxicity and …