Alterations of gut microbiota have been implicated in multiple diseases including cancer.
However, the gut microbiota spectrum in lung cancer remains largely unknown. Here we …

Macrophages are the key regulator of T-cell responses depending on their activation state.
CC motif chemokine receptor-like 2 (CCRL2), a nonsignaling atypical receptor originally …

Fever is an evolutionarily conserved response that confers survival benefits during infection.
However, the underlying mechanism remains obscure. Here, we report that fever promoted …

Coronavirus disease 2019 (COVID-19) has spread globally as a severe pandemic, which is
caused by a novel coronavirus named Severe Acute Respiratory Syndrome coronavirus 2 (…

Intestinal stem cell (ISC) differentiation is regulated precisely by a niche in the crypt, where
lymphocytes may interact with stem and transient amplifying (TA) cells. However, whether …

Breast cancer is a heterogeneous disease. In particular, triple-negative breast cancer (TNBC)
comprises various molecular subgroups with unclear identities and currently has few …

Intrahepatic cholestasis of pregnancy (ICP) is a cholestatic disorder with potentially deleterious
consequences for fetuses. Although a clear correlation between the elevated levels of …

Tumor metastasis is the leading cause of cancer-associated mortality. Unfortunately, the
underlying mechanism of metastasis is poorly understood. Expression of legumain (LGMN), an …

Dynamic regulation of integrin activation and inactivation is critical for precisely controlled cell
adhesion and migration in physiological and pathological processes. The molecular basis …

The protein C receptor (Procr) has been implicated as a stem cell surface marker in several
tissues. It is unknown whether Procr acts as a functional signaling receptor in stem cells. Here…