[HTML][HTML] Animal models for COVID-19: advances, gaps and perspectives
C Fan, Y Wu, X Rui, Y Yang, C Ling, S Liu… - … and Targeted Therapy, 2022 - nature.com
COVID-19, caused by SARS-CoV-2, is the most consequential pandemic of this century.
Since the outbreak in late 2019, animal models have been playing crucial roles in aiding the …
Since the outbreak in late 2019, animal models have been playing crucial roles in aiding the …
[HTML][HTML] A vaccine targeting the RBD of the S protein of SARS-CoV-2 induces protective immunity
…, X Ma, S Chen, M Gou, W Huang, Y Wang, C Fan… - Nature, 2020 - nature.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes a respiratory disease
called coronavirus disease 2019 (COVID-19), the spread of which has led to a pandemic. …
called coronavirus disease 2019 (COVID-19), the spread of which has led to a pandemic. …
A noncompeting pair of human neutralizing antibodies block COVID-19 virus binding to its receptor ACE2
…, H Xiao, Z Fan, S Tan, G Wu, W Tan, X Lu, C Fan… - Science, 2020 - science.org
Neutralizing antibodies could potentially be used as antivirals against the coronavirus disease
2019 (COVID-19) pandemic. Here, we report isolation of four human-origin monoclonal …
2019 (COVID-19) pandemic. Here, we report isolation of four human-origin monoclonal …
Establishment and validation of a pseudovirus neutralization assay for SARS-CoV-2
…, M Wang, Q Lu, X Li, Q Sun, J Liu, C Fan… - Emerging microbes & …, 2020 - Taylor & Francis
Pseudoviruses are useful virological tools because of their safety and versatility, especially
for emerging and re-emerging viruses. Due to its high pathogenicity and infectivity and the …
for emerging and re-emerging viruses. Due to its high pathogenicity and infectivity and the …
Structural basis for neutralization of SARS-CoV-2 and SARS-CoV by a potent therapeutic antibody
Z Lv, YQ Deng, Q Ye, L Cao, CY Sun, C Fan, W Huang… - Science, 2020 - science.org
The coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) has resulted in an unprecedented public health crisis. …
syndrome coronavirus 2 (SARS-CoV-2) has resulted in an unprecedented public health crisis. …
[HTML][HTML] Quantification of SARS-CoV-2 neutralizing antibody by a pseudotyped virus-based assay
…, H Qin, M Wang, Q Lu, X Li, Q Sun, J Liu, C Fan… - Nature protocols, 2020 - nature.com
Pseudotyped viruses are useful virological tools because of their safety and versatility. On
the basis of a vesicular stomatitis virus (VSV) pseudotyped virus production system, we …
the basis of a vesicular stomatitis virus (VSV) pseudotyped virus production system, we …
[HTML][HTML] Novel cleavage sites identified in SARS-CoV-2 spike protein reveal mechanism for cathepsin L-facilitated viral infection and treatment strategies
…, J Lu, Q He, MJ Li, RX Zhao, H Wang, W Huang, C Fan… - Cell discovery, 2022 - nature.com
The spike (S) protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is
an important target for vaccine and drug development. However, the rapid emergence of …
an important target for vaccine and drug development. However, the rapid emergence of …
[HTML][HTML] Antibody-dependent-cellular-cytotoxicity-inducing antibodies significantly affect the post-exposure treatment of Ebola virus infection
Q Liu, C Fan, Q Li, S Zhou, W Huang, L Wang, C Sun… - Scientific reports, 2017 - nature.com
Passive immunotherapy with monoclonal antibodies (mAbs) is an efficacious treatment for
Ebola virus (EBOV) infections in animal models and humans. Understanding what constitutes …
Ebola virus (EBOV) infections in animal models and humans. Understanding what constitutes …
[PDF][PDF] A mouse model of SARS-CoV-2 infection and pathogenesis
…, QM Liu, YL Shen, Y Zhou, X Yang, TY Zhao, CF Fan… - Cell host & …, 2020 - cell.com
Since December 2019, a novel coronavirus SARS-CoV-2 has emerged and rapidly spread
throughout the world, resulting in a global public health emergency. The lack of vaccine and …
throughout the world, resulting in a global public health emergency. The lack of vaccine and …
[HTML][HTML] Histones released by NETosis enhance the infectivity of SARS-CoV-2 by bridging the spike protein subunit 2 and sialic acid on host cells
…, Y Peng, C Huang, Z Qian, W Cheng, C Fan… - Cellular & Molecular …, 2022 - nature.com
Neutrophil extracellular traps (NETs) can capture and kill viruses, such as influenza viruses,
human immunodeficiency virus (HIV), and respiratory syncytial virus (RSV), thus contributing …
human immunodeficiency virus (HIV), and respiratory syncytial virus (RSV), thus contributing …