Background During neuroinflammation many chemokines alter the function of the blood-brain
barrier (BBB) that regulates the entry of macromolecules and immune cells into the brain. …

Background A poorly functioning tumor vasculature is pro-oncogenic and may impede the
delivery of therapeutics. Normalizing the vasculature, therefore, may be beneficial. We …

Pathological angiogenesis contributes to morbidity in a number of diseases including cancer,
diabetic retinopathy and the neovascular form of age-related macular degeneration, …

Experimental Autoimmune Uveitis (EAU) is driven by immune cells responding to self-antigens.
Many features of this non-infectious, intraocular inflammatory disease model recapitulate …

In recent years improving tumor vascular function, to render the tumour microenvironment
less permissive and to improve delivery of therapeutics, has gained traction due to a growing …

… I, Chantelle Elizabeth Bowers, confirm that the research presented throughout this thesis
is my own unless otherwise stated. Studies on EAE (experimental autoimmune …

Cytotoxic T-lymphocyte-associated antigen-4 (CTLA-4) is an essential regulator of T-cell
responses, and its absence precipitates lethal T-cell hyperactivity. However, whether CTLA-4 …

Inflammation and fibrosis are important components of diseases that contribute to the malfunction
of epithelia and endothelia. The Rho guanine nucleotide exchange factor (GEF) GEF-…

… Data for the readmission rate were retrieved by the facility's data management coordinator
through electronic audit and compared with the data from the prior year. Electronic medical …

… Using an automated search of the electronic prescribing records of the remaining 109 clinics,
we identified 13 657 eligible patients who were sent an introductory letter with 14 days to …