Physical interactions between proteins are essential for most biological processes governing
life 1 . However, the molecular determinants of such interactions have been challenging to …

Reverse transcription-derived sequences account for at least half of the human genome.
Although these retroelements are formidable motors of evolution, they can occasionally cause …

The detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)–specific
antibodies in the serum of an individual indicates previous infection or vaccination. However, …

The SARS-CoV-2 Omicron variant has very high levels of transmission, is resistant to
neutralization by authorized therapeutic human monoclonal antibodies (mAb) and is less sensitive …

Background More than two years into the COVID-19 pandemic, most of the population has
developed anti-SARS-CoV-2 antibodies from infection and/or vaccination. However, public …

SARS-CoV-2 virions are surrounded by a lipid bilayer that contains membrane proteins such
as spike, responsible for target-cell binding and virus fusion. We found that during SARS-…

Control of the ongoing SARS-CoV-2 pandemic is endangered by the emergence of viral
variants with increased transmission efficiency, resistance to marketed therapeutic antibodies, …

In the first days of embryogenesis, transposable element–embedded regulatory sequences (TEeRS)
are silenced by Kruppel-associated box (KRAB) zinc finger proteins (KZFPs). Many …

De novo DNA methylation is an essential aspect of the epigenetic reprogramming that takes
place during early development, yet factors responsible for its instatement at particular …

TRIM28 (also known as KAP1 or TIF1β) is the universal co-repressor of the Krüppel-associated
box-containing zinc finger proteins (Krab-ZFPs), the largest family of transcription factors …