User profiles for Charles B Stauft

Charles Brandon Stauft

Verified email at fda.hhs.gov
Cited by 1008

Large-scale recoding of an arbovirus genome to rebalance its insect versus mammalian preference

SH Shen, CB Stauft, O Gorbatsevych… - Proceedings of the …, 2015 - National Acad Sciences
The protein synthesis machineries of two distinct phyla of the Animal kingdom, insects of
Arthropoda and mammals of Chordata, have different preferences for how to best encode …

SARS-CoV-2 infection induces protective immunity and limits transmission in Syrian hamsters

P Selvaraj, CZ Lien, S Liu, CB Stauft… - Life science …, 2021 - life-science-alliance.org
A critical question in understanding the immunity to SARS-COV-2 is whether recovered
patients are protected against re-challenge and transmission upon second exposure. We …

[HTML][HTML] Intranasal or airborne transmission-mediated delivery of an attenuated SARS-CoV-2 protects Syrian hamsters against new variants

CB Stauft, P Selvaraj, F D'Agnillo, CA Meseda… - Nature …, 2023 - nature.com
Detection of secretory antibodies in the airway is highly desirable when evaluating mucosal
protection by vaccines against a respiratory virus, such as the severe acute respiratory …

[HTML][HTML] Intranasal delivery of a rationally attenuated SARS-CoV-2 is immunogenic and protective in Syrian hamsters

S Liu, CB Stauft, P Selvaraj, P Chandrasekaran… - Nature …, 2022 - nature.com
Few live attenuated severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
vaccines are in pre-clinical or clinical development. We seek to attenuate SARS-CoV-2 (isolate …

A codon-pair deoptimized live-attenuated vaccine against respiratory syncytial virus is immunogenic and efficacious in non-human primates

S Mueller, CB Stauft, R Kalkeri, F Koidei, A Kushnir… - Vaccine, 2020 - Elsevier
Despite a critical need for a respiratory syncytial virus (RSV) vaccine and decades of
development efforts, a vaccine to protect infants, elderly, and other at-risk populations from RSV …

Dengue and Zika virus 5′ untranslated regions harbor internal ribosomal entry site functions

Y Song, JA Mugavero, CB Stauft, E Wimmer - MBio, 2019 - Am Soc Microbiol
The Flavivirus genus of the Flaviviridae family encompasses numerous enveloped plus-strand
RNA viruses. Dengue virus (DENV), a flavivirus, is the leading cause of serious arthropod-…

Structure–function analysis of resistance to bamlanivimab by SARS-CoV-2 variants Kappa, Delta, and Lambda

…, T Huynh, CB Stauft, TT Wang, B Luan - Journal of Chemical …, 2021 - ACS Publications
The newly emerging Kappa, Delta, and Lambda SARS-CoV-2 variants are worrisome,
characterized with the double mutations E484Q/L452R, T478K/L452R, and F490S/L452Q, …

[PDF][PDF] Epitope diversity of SARS-CoV-2 hyperimmune intravenous human immunoglobulins and neutralization of variants of concern

…, G Grubbs, C Huang, CB Stauft, T Wang, B Golding… - IScience, 2021 - cell.com
Hyperimmune immunoglobulin (hCoV-2IG) generated from SARS-CoV-2 convalescent
plasma (CP) are under evaluation in clinical trials. Here we explored the antibody epitope …

[HTML][HTML] MVA vector expression of SARS-CoV-2 spike protein and protection of adult Syrian hamsters against SARS-CoV-2 challenge

CA Meseda, CB Stauft, P Selvaraj, CZ Lien, C Pedro… - Npj Vaccines, 2021 - nature.com
Numerous vaccine candidates against SARS-CoV-2, the causative agent of the COVID-19
pandemic, are under development. The majority of vaccine candidates to date are designed …

Entry sites of Venezuelan and western equine encephalitis viruses in the mouse central nervous system following peripheral infection

AT Phillips, AB Rico, CB Stauft, SL Hammond… - Journal of …, 2016 - Am Soc Microbiol
Venezuelan and western equine encephalitis viruses (VEEV and WEEV; Alphavirus ;
Togaviridae ) are mosquito-borne pathogens causing central nervous system (CNS) disease in …