Dual-mechanism estrogen receptor inhibitors
…, ES Rangarajan, CC Nettles… - Proceedings of the …, 2021 - National Acad Sciences
Efforts to improve estrogen receptor-α (ER)–targeted therapies in breast cancer have relied
upon a single mechanism, with ligands having a single side chain on the ligand core that …
upon a single mechanism, with ligands having a single side chain on the ligand core that …
Chemical systems biology reveals mechanisms of glucocorticoid receptor signaling
…, JC Nwachukwu, S Srinivasan, CC Nettles… - Nature chemical …, 2021 - nature.com
Glucocorticoids display remarkable anti-inflammatory activity, but their use is limited by on-target
adverse effects including insulin resistance and skeletal muscle atrophy. We used a …
adverse effects including insulin resistance and skeletal muscle atrophy. We used a …
Chemical Systems Biology Reveals Mechanisms of Dissociated Glucocorticoid Receptor Signaling
Glucocorticoids display remarkable anti-inflammatory activity, but their use is limited by on-target
adverse effects including insulin resistance and skeletal muscle atrophy. We used a …
adverse effects including insulin resistance and skeletal muscle atrophy. We used a …
[PDF][PDF] Dual-Mechanism Estrogen Receptor Inhibitors Reveal an Ensemble of Binding Modes for Robust Breast Cancer Antagonism
…, S Srinivasan, ES Rangarajan, CC Nettles… - scholar.archive.org
Current antiestrogen therapies for estrogen receptor alpha (ERα)-positive breast cancers work
only by direct antagonism, using a single side chain that extends outward from the ligand …
only by direct antagonism, using a single side chain that extends outward from the ligand …
Using water Raman intensities to determine the effective excitation and emission path lengths of fluorophotometers for correcting fluorescence inner filter effect
CB Nettles, J Hu, D Zhang - Analytical chemistry, 2015 - ACS Publications
Fluorescence and Raman inner filter effects (IFE) cause spectral distortion and nonlinearity
between spectral signal intensity with increasing analyte concentration. Convenient and …
between spectral signal intensity with increasing analyte concentration. Convenient and …
On-resonance fluorescence, resonance Rayleigh scattering, and ratiometric resonance synchronous spectroscopy of molecular-and quantum dot-fluorophores
K Siriwardana, CB Nettles, BCN Vithanage… - Analytical …, 2016 - ACS Publications
Existing studies on molecular fluorescence have almost exclusively been focused on Stokes-shifted
fluorescence spectroscopy (SSF) in which the emitted photon is detected at the …
fluorescence spectroscopy (SSF) in which the emitted photon is detected at the …
UV–Vis ratiometric resonance synchronous spectroscopy for determination of nanoparticle and molecular optical cross sections
… C solv and C NP are the solvent and NP concentrations, respectively. σ Sca Solv (λ), σ
Sca NP (λ), and σ OFE NP (λ) are the solvent and NP scattering cross sections and NP on-…
Sca NP (λ), and σ OFE NP (λ) are the solvent and NP scattering cross sections and NP on-…
A generalized model on the effects of nanoparticles on fluorophore fluorescence in solution
D Zhang, CB Nettles - The Journal of Physical Chemistry C, 2015 - ACS Publications
Nanoparticles (NP) can modify fluorophore fluorescence in solution through multiple pathways
that include fluorescence inner filter effect (IFE), dynamic and static quenching, surface …
that include fluorescence inner filter effect (IFE), dynamic and static quenching, surface …
Direct observation of ion pairing at the liquid/solid interfaces by surface enhanced raman spectroscopy
Ion-pairing, the association of oppositely charged ionic species in solution and at liquid/solid
interfaces has been proposed as a key factor for a wide range of physicochemical …
interfaces has been proposed as a key factor for a wide range of physicochemical …
Then and now: A 50‐year retrospective thematic analysis of Society for Community Research and Action presidential addresses
CD Nettles, MM Schlehofer… - American Journal of …, 2023 - Wiley Online Library
The Society for Community Research and Action (SCRA) is the primary professional home
for community psychologists in the United States and increasingly around the world. Since …
for community psychologists in the United States and increasingly around the world. Since …