Emerging evidence has suggested that the capability of a tumor to grow and propagate is
dependent on a small subset of cells within a tumor, termed cancer stem cells. Although data …

The oxidation of glucose represents a major source of metabolic energy for mammaliancells.
However, because the plasma membrane is impermeable to polar molecules such as …

Mammalian apolipoprotein B (apo B) exists in two forms, each the product of a single gene.
The shorter form, apo B48, arises by posttranscriptional RNA editing whereby cytidine …

Immune cells are somewhat unique in that activation responses can alter quantitative
phenotypes upwards of 100,000-fold. To date little is known about the metabolic adaptations …

Dehydroascorbic acid (DHA) is rapidly taken up by cells and reduced to ascorbic acid (AA).
Using the Xenopus laevis oocyte expression system we examined transport of DHA and AA …

The regulation of synthesis, degradation, and distribution of lipids is crucial for homeostasis
of organisms and cells. The sterol regulatory element-binding protein (SREBP) transcription …

Heightened impulsivity and inefficient inhibitory control are increasingly recognized as risk
factors for unhealthy eating and obesity but the underlying processes are not fully understood…

Few studies have explored the impact of rare variants (minor allele frequency < 1%) on highly
heritable plasma metabolites identified in metabolomic screens. The Finnish population …

K ATP channels couple the intracellular energy state to membrane excitability and regulate
a wide array of biologic activities. K ATP channels contain a pore-forming inwardly rectifying …

… Address correspondence and reprint requests to Charles F. Burant, MD, PhD, MC1027,
University of Chicago, 5841 S. Maryland Ave., Chicago, IL 60637. E-mail: cburant@medicine.bsd…