The mammalian Pcdhg gene cluster encodes a family of 22 cell adhesion molecules, the
gamma-Protocadherins (γ-Pcdhs), critical for neuronal survival and neural circuit formation. …

Cell adhesion molecules (CAMs) are key players in the formation of neural circuits during
development. The γ-protocadherins (γ-Pcdhs), a family of 22 CAMs encoded by the Pcdhg …

Genome manipulation methods in C. elegans require microinjecting DNA or ribonucleoprotein
complexes into the microscopic core of the gonadal syncytium. These microinjections are …

The Pcdhg gene cluster encodes 22 γ-Protocadherin (γ-Pcdh) cell adhesion molecules that
critically regulate multiple aspects of neural development, including neuronal survival, …

Background: Retrospective analyses have demonstrated significantly improved survival for
AYA ALL patients (pts) aged 16-21 years (yrs) when treated on pediatric versus adult US NCI …

Background Philadelphia chromosome–like acute lymphoblastic leukemia (Ph-like ALL) is
characterized by a gene-expression profile similar to that of BCR–ABL1–positive ALL, …

Retrospective studies have suggested that older adolescents and young adults (AYAs) with
acute lymphoblastic leukemia (ALL) have better survival rates when treated using a pediatric …

Chromosomal rearrangements deregulating hematopoietic transcription factors are common
in acute lymphoblastic leukemia (ALL). Here we show that deregulation of the homeobox …

Purpose Philadelphia chromosome (Ph)–like acute lymphoblastic leukemia (ALL) is a high-risk
subtype of childhood ALL characterized by kinase-activating alterations that are …

Chromosomal rearrangements are initiating events in acute lymphoblastic leukaemia (ALL).
Here using RNA sequencing of 560 ALL cases, we identify rearrangements between …