Understanding the metabolic consequences of heart failure is important in evaluating potential
mechanisms for disease progression and assessing targets for therapies designed to …

Background—Use of β-adrenoreceptor blockade in the treatment of heart failure has been
associated with a reduction in myocardial oxygen consumption and an improvement in …

The prefrontal cortex (PFC) has been well known for its role in higher order cognition, affect
regulation and social reasoning. Although the precise underpinnings have not been …

An optimal method for determining left ventricular ejection fraction (LVEF) by echocardiography
should be rapid, reliable, and widely applicable in order to be utilized routinely in a busy …

Tau PET imaging has potential for elucidating changes in the deposition of neuropathological
tau aggregates that are occurring during the progression of Alzheimer disease (AD). This …

This study investigated differences in retrospective cognitive trajectories between amyloid
and tau PET biomarker stratified groups in initially cognitively unimpaired participants …

Introduction This study applies a novel algorithm to longitudinal amyloid positron emission
tomography (PET) imaging to identify age‐heterogeneous amyloid trajectory groups, estimate …

This study compared the in vivo imaging characteristics of tau PET ligands 18 F-THK-5351
and 18 F-THK-5317 in the context of Alzheimer disease (AD). Additionally, reference tissue …

Introduction Down syndrome (DS) arises from a triplication of chromosome 21, causing
overproduction of the amyloid precursor protein and predisposes individuals to early Alzheimer's …

Alzheimer’s disease biomarkers are becoming increasingly important for characterizing the
longitudinal course of disease, predicting the timing of clinical and cognitive symptoms, and …