Rapidly spreading new variants of SARS-CoV-2 carry multiple mutations in the viral spike
protein which attaches to the angiotensin converting enzyme 2 (ACE2) receptor on host cells. …

Transcription-coupled nucleotide-excision repair (TC-NER) is a subpathway of NER that
efficiently removes the highly toxic RNA polymerase II blocking lesions in DNA. Defective TC-…

CRISPR-Cas are prokaryotic adaptive immune systems. Cas nucleases generally use
CRISPR-derived RNA guides to specifically bind and cleave DNA or RNA targets. Here, we …

RNA-guided type V CRISPR–Cas12 effectors provide adaptive immunity against mobile
genetic elements (MGEs) in bacteria and archaea. Among diverse Cas12 enzymes, the recently …

The genetic causes of primary antibody deficiencies and autism spectrum disorder (ASD)
are largely unknown. Here, we report a patient with hypogammaglobulinemia and ASD who …

CRISPR-Cas9 systems are enriched in human pathogenic bacteria and have been linked to
cytotoxicity by an unknown mechanism. Here, we show that upon infection of human cells, …

DNA mismatch repair detects and removes mismatches from DNA by a conserved mechanism,
reducing the error rate of DNA replication by 100- to 1,000-fold. In this process, MutS …

Hyperthermia has a number of biological effects that sensitize tumors to radiotherapy in the
range between 40-44 C. One of these effects is heat-induced degradation of BRCA2 that in …

DNA mismatch repair (MMR) maintains genome stability through repair of DNA replication
errors. In Escherichia coli, initiation of MMR involves recognition of the mismatch by MutS, …

Protein ubiquitination plays an important role in the regulation of many cellular processes,
including protein degradation, cell cycle regulation, apoptosis, and DNA repair. To study the …