Background Myeloproliferative neoplasms, such as polycythemia vera, essential thrombocythemia,
and myelofibrosis, are chronic hematologic cancers with varied progression rates. …

Genome-wide DNA sequencing was used to decrypt the phylogeny of multiple samples from
distinct areas of cancer and morphologically normal tissue taken from the prostates of three …

The androgen receptor (AR) regulates prostate cell growth in man, and prostate cancer is the
commonest cancer in men in the UK. We present a comprehensive analysis of AR binding …

Retinoic acid receptor-α (RARα) is a known estrogen target gene in breast cancer cells. The
consequence of RARα induction by estrogen was previously unknown. We now show that …

The extracellular matrix (ECM) can induce chemotherapy resistance via AKT-mediated
inhibition of apoptosis. Here, we show that loss of the ECM protein TGFBI (transforming growth …

Prostate cancer represents a substantial clinical challenge because it is difficult to predict
outcome and advanced disease is often fatal. We sequenced the whole genomes of 112 …

Metabolic adaptation is considered an emerging hallmark of cancer, whereby cancer cells
exhibit high rates of glucose consumption with consequent lactate production. To ensure …

Somatic mutations in JAK2, CALR and MPL are found in the majority of myeloproliferative
neoplasms (MPN) but many patients also harbor somatic mutations in epigenetic regulators of …

The prostate gland produces prostatic fluid, high in zinc and citrate and essential for the
maintenance of spermatozoa. Prostate cancer is a common condition with limited treatment …

Background Bacteria play a suspected role in the development of several cancer types, and
associations between the presence of particular bacteria and prostate cancer have been …