One of the grand challenges of bottom-up synthetic biology is the development of minimal
machineries for cell division. The mechanical transformation of large-scale compartments, …

Focal adhesions (FAs) are protein machineries essential for cell adhesion, migration, and
differentiation. Talin is an integrin-activating and tension-sensing FA component directly …

Focal adhesions (FA) are large macromolecular assemblies which help transmit mechanical
forces and regulatory signals between the extracellular matrix and an interacting cell. Two …

Individually, dysfunction of both the endoplasmic reticulum (ER) and mitochondria has been
linked to aging, but how communication between these organelles might be targeted to …

Eukaryotic cells are defined by extensive intracellular compartmentalization, which requires
dynamic membrane remodeling. FER/Cip4 homology-Bin/amphiphysin/Rvs (F-BAR) domain …

F-BAR domain proteins regulate and sense membrane curvature by interacting with negatively
charged phospholipids and assembling into higher-order scaffolds. However, regulatory …

Membrane remodeling by Fes/Cip4 homology-Bin/Amphiphysin/Rvs167 (F-BAR) proteins is
regulated by autoinhibitory interactions between their SRC homology 3 (SH3) and F-BAR …

Synaptic membrane-remodeling events such as endocytosis require force-generating actin
assembly. The endocytic machinery that regulates these actin and membrane dynamics …

Productive and coordinated tissue contraction requires spatiotemporal regulation of myosin
activity. We use the contractile myoepithelial cells of the Caenorhabditis elegans …

The reproductive system of the hermaphroditic nematode C. elegans consists of a series of
contractile cell types—including the gonadal sheath cells, the spermathecal cells and the …