Microglia have fundamental roles in health and disease; however, effects of age, sex, and
genetic factors on human microglia have not been fully explored. We applied bulk and single‐…

Vast numbers of differentially expressed genes and perturbed networks have been identified
in Alzheimer’s disease (AD), however, neither disease nor brain region specificity of these …

Methods: We evaluated 321 African Americans (159 AD, 162 controls) from the Florida
Consortium for African-American Alzheimer’s Disease Studies (FCA 3 DS). Five plasma proteins …

Cerebral amyloid angiopathy (CAA) contributes to accelerated cognitive decline in Alzheimer’s
disease (AD) dementia and is a common finding at autopsy. The APOEε4 allele and male …

Background and Objectives Putative loss-of-function (pLOF) ABCA7 variants that increase
Alzheimer disease (AD) risk were identified; however, deep phenotypic characterization of …

Blood-brain barrier (BBB) dysfunction is well-known in Alzheimer’s disease (AD), but the
precise molecular changes contributing to its pathophysiology are unclear. To understand the …

Background African Americans (AA) remain underrepresented in Alzheimer's disease (AD)
research, despite the prevalence of AD being double in AA compared to non-Hispanic whites…

Microglia have fundamental roles in health and disease, however effects of age, sex and
genetic factors on human microglia have not been fully explored. We applied bulk and single …

Background Given the overlap of symptoms between Alzheimer’s disease (AD) and other
dementias, it is essential to develop widely accessible biomarkers that will ensure an accurate …

Background African Americans (AA) remain underrepresented in Alzheimer’s disease (AD)
research, despite the prevalence of AD being ∼2X higher in this population compared to non…