In recent years it has become clear that cancer cells within a single tumor can display striking
morphological, genetic and behavioral variability. Burgeoning genetic, epigenetic and …

Ductal carcinoma in situ (DCIS) is an intraductal neoplastic proliferation of epithelial cells
that is separated from the breast stroma by an intact layer of basement membrane and …

The field of cancer diagnostics has recently been impacted by new and exciting developments
in the area of liquid biopsy. A liquid biopsy is a minimally invasive alternative to surgical …

Cell-free circulating tumour DNA (ctDNA) in plasma has been shown to be informative of the
genomic alterations present in tumours and has been used to monitor tumour progression …

Metastasis is the main cause of death for patients with breast cancer. Many studies have
characterized the genomic landscape of breast cancer during its early stages. However, there is …

Background The major clinical challenge in the treatment of high-grade serous ovarian cancer
(HGSOC) is the development of progressive resistance to platinum-based chemotherapy. …

Hepatocellular carcinoma (HCC) is the most common primary liver cancer and the second
most frequent cause of cancer-related mortality worldwide. The multikinase inhibitor sorafenib …

Purpose: Resistance to platinum-based chemotherapy or PARP inhibition in germline BRCA1
or BRCA2 mutation carriers may occur through somatic reversion mutations or intragenic …

Mutations in genes encoding proteins involved in RNA splicing have been found to occur at
relatively high frequencies in several tumour types including myelodysplastic syndromes, …

Polymorphous low-grade adenocarcinoma (PLGA) is the second most frequent type of malignant
tumor of the minor salivary glands. We identified PRKD1 hotspot mutations encoding p.…