[PDF][PDF] Insulin potentiates JAK/STAT signaling to broadly inhibit flavivirus replication in insect vectors

LRH Ahlers, CE Trammell, GF Carrell, S Mackinnon… - Cell reports, 2019 - cell.com
The World Health Organization estimates that more than half of the world's population is at
risk for vector-borne diseases, including arboviruses. Because many arboviruses are …

Early steps in herpes simplex virus infection blocked by a proteasome inhibitor

SM Schneider, SM Pritchard, GA Wudiri, CE Trammell… - MBio, 2019 - Am Soc Microbiol
Viruses commandeer host cell 26S proteasome activity to promote viral entry, gene expression,
replication, assembly, and egress. Proteasomal degradation activity is critical for herpes …

[HTML][HTML] Emerging mechanisms of insulin-mediated antiviral immunity in Drosophila melanogaster

CE Trammell, AG Goodman - Frontiers in immunology, 2019 - frontiersin.org
Arboviruses (arthropod-borne viruses), such as Zika (ZIKV), West Nile (WNV), and dengue (DENV)
virus, include some of the most significant global health risks to human populations. …

[HTML][HTML] Host factors that control mosquito-borne viral infections in humans and their vector

CE Trammell, AG Goodman - Viruses, 2021 - mdpi.com
Mosquito-borne viral infections are responsible for a significant degree of morbidity and
mortality across the globe due to the severe diseases these infections cause, and they continue …

[HTML][HTML] Coupled small molecules target RNA interference and JAK/STAT signaling to reduce Zika virus infection in Aedes aegypti

CE Trammell, G Ramirez, I Sanchez-Vargas… - PLoS …, 2022 - journals.plos.org
The recent global Zika epidemics have revealed the significant threat that mosquito-borne
viruses pose. There are currently no effective vaccines or prophylactics to prevent Zika virus (…

Insulin-mediated endothelin signaling is antiviral during West Nile virus infection

CE Trammell, EH Rowe, AB Char, BJ Jones… - Journal of …, 2023 - Am Soc Microbiol
West Nile virus (WNV) is the most prevalent mosquito-borne virus in the United States with
approximately 2,000 cases each year. There are currently no approved human vaccines and …

Targeting insulin-mediated activation of the PI3K/AKT axis to reduce flavivirus infection in humans and mosquitoes

CE Trammell - 2022 - search.proquest.com
… To the Faculty of Washington State University: The members of the Committee appointed to
examine the dissertation of CHASITY E. TRAMMELL find it satisfactory and recommend that …

[PDF][PDF] AI for the repurposing of approved or investigational drugs against COVID-19

K Avchaciov, O Burmistrova, PO Fedichev - Research Gate, 2020 - researchgate.net
The coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2), has spread globally since 2019 and reached the pandemic level …

To die or not to die: Programmed cell death responses and their interactions with Coxiella burnetii infection

CA Osbron, AG Goodman - Molecular microbiology, 2022 - Wiley Online Library
Coxiella burnetii is a Gram‐negative, obligate intracellular, macrophage‐tropic bacterium,
and the causative agent of the zoonotic disease Q fever. The epidemiology of Q fever is …

[HTML][HTML] The 23rd Annual Meeting of the Rocky Mountain Virology Association

AL Brehm, TJ Dunham, SM Pinto, KA Williams… - 2024 - mdpi.com
… that more efficiently transmits to the E background and became lymphotropic, resembling …
Chasity E. Trammell presented their joint work with Brian J. Geiss and Gregory D. Ebel (Dept…