Glycemic traits are used to diagnose and monitor type 2 diabetes and cardiometabolic health.
To date, most genetic studies of glycemic traits have focused on individuals of European …

Subcutaneous adipose tissue stores excess lipids and maintains energy balance. We performed
expression quantitative trait locus (eQTL) analyses by using abdominal subcutaneous …

Increased adiposity is a hallmark of obesity and overweight, which affect 2.2 billion people
world-wide. Understanding the genetic and molecular mechanisms that underlie obesity-…

Genome-wide association studies (GWASs) have identified thousands of genetic loci
associated with cardiometabolic traits including type 2 diabetes (T2D), lipid levels, body fat …

Integration of genome-wide association study (GWAS) signals with expression quantitative
trait loci (eQTL) studies enables identification of candidate genes. However, evaluating …

Alternate splicing events can create isoforms that alter gene function, and genetic variants
associated with alternate gene isoforms may reveal molecular mechanisms of disease. We …

Comprehensive metabolite profiling captures many highly heritable traits, including amino
acid levels, which are potentially sensitive biomarkers for disease pathogenesis. To better …

Circulating levels of adiponectin, an adipocyte-secreted protein associated with cardiovascular
and metabolic risk, are highly heritable. To gain insights into the biology that regulates …

To identify genetic contributions to type 2 diabetes (T2D) and related glycemic traits (fasting
glucose, fasting insulin, and HbA1c), we conducted genome-wide association analyses (…

Loci identified in genome-wide association studies (GWAS) can include multiple distinct
association signals. We sought to identify the molecular basis of multiple association signals for …