Disruption and therapeutic rescue of autophagy in a human neuronal model of Niemann Pick type C1

MP Ordonez, EA Roberts, CU Kidwell… - Human molecular …, 2012 - academic.oup.com
An unresolved issue about many neurodegenerative diseases is why neurons are particularly
sensitive to defects in ubiquitous cellular processes. One example is Niemann Pick type …

Transferred mitochondria accumulate reactive oxygen species, promoting proliferation

CU Kidwell, JR Casalini, S Pradeep, SD Scherer… - Elife, 2023 - elifesciences.org
Recent studies reveal that lateral mitochondrial transfer, the movement of mitochondria from
one cell to another, can affect cellular and tissue homeostasis. Most of what we know about …

The biochemical basis of mitochondrial dysfunction in Zellweger Spectrum Disorder

…, S Lettlova, JA Berg, YC Chen, CU Kidwell… - EMBO …, 2021 - embopress.org
Peroxisomal biogenesis disorders (PBDs) are genetic disorders of peroxisome biogenesis
and metabolism that are characterized by profound developmental and neurological …

[HTML][HTML] Multiple zebrafish atoh1 genes specify a diversity of neuronal types in the zebrafish cerebellum

CU Kidwell, CY Su, M Hibi, CB Moens - Developmental biology, 2018 - Elsevier
A single Atoh1 basic-helix-loop-helix transcription factor specifies multiple neuron types in
the mammalian cerebellum and anterior hindbrain. The zebrafish genome encodes three …

Laterally transferred macrophage mitochondria act as a signaling source promoting cancer cell proliferation

CU Kidwell, JR Casalini, S Pradeep, SD Scherer… - bioRxiv, 2021 - biorxiv.org
Lateral transfer of mitochondria occurs in many physiological and pathological conditions.
Given that mitochondria provide essential energy for cellular activities, mitochondrial transfer …

Msp1/ATAD1 restores mitochondrial function in Zellweger Spectrum Disease

…, JM Winter, S Lettlova, JA Berg, YC Chen, CU Kidwell… - bioRxiv, 2020 - biorxiv.org
Peroxisomal Biogenesis Disorders (PBDs) are a class of inherited metabolic disorders with
profound neurological and other phenotypes. The most severe PBDs are caused by …

Multiple zebrafish atoh1 genes specify a diversity of neuronal types in the zebrafish hindbrain

CU Kidwell - 2016 - digital.lib.washington.edu
… a diversity of neuronal types in the zebrafish hindbrain Chelsea U. Kidwell A dissertati … Not
surprisingly, MHB atoh1c expression is lost under conditions where Fgf and Wnt signaling are …

Cerebellar Neuron Diversity in the Zebrafish: More atoh1 Genes for More atoh1 Fates?

CB Moens, CU Kidwell - The FASEB Journal, 2018 - Wiley Online Library
During mammalian cerebellar development, a single Atoh1 basic‐helix‐loop‐helix
transcription factor is required sequentially for the specification of multiple neuron types. The …

Epidemiological impact in the United States of a tissue-based definition of transient ischemic attack

B Ovbiagele, CS Kidwell, JL Saver - Stroke, 2003 - Am Heart Assoc
Background and Purpose— The traditional definition of transient ischemic attack (TIA),
based on an arbitrary time criterion of symptom resolution within 24 hours, is problematic …

Thrombolytic reversal of acute human cerebral ischemic injury shown by diffusion/perfusion magnetic resonance imaging

CS Kidwell, JL Saver, J Mattiello… - Annals of Neurology …, 2000 - Wiley Online Library
… In various series, between 62% and 88% of patients imaged initially under 6 hours … Studies
that include larger numbers of patients undergoing thrombolytic therapy may allow more …