Encephalomyocarditis virus disrupts stress granules, the critical platform for triggering antiviral innate immune responses
CS Ng, M Jogi, JS Yoo, K Onomoto, S Koike… - Journal of …, 2013 - Am Soc Microbiol
In response to stress, cells induce ribonucleoprotein aggregates, termed stress granules (SGs).
SGs are transient loci containing translation-stalled mRNA, which is eventually degraded …
SGs are transient loci containing translation-stalled mRNA, which is eventually degraded …
[HTML][HTML] Spatio-temporal characterization of the antiviral activity of the XRN1-DCP1/2 aggregation against cytoplasmic RNA viruses to prevent cell death
CS Ng, DM Kasumba, T Fujita, H Luo - Cell Death & Differentiation, 2020 - nature.com
Host nucleases are implicated in antiviral response through the processing of pathogen-derived
nucleic acids. Among many host RNases, decapping enzymes DCP1 and 2, and 5′→3…
nucleic acids. Among many host RNases, decapping enzymes DCP1 and 2, and 5′→3…
[HTML][HTML] Dysregulation of RNA-binding proteins in amyotrophic lateral sclerosis
YC Xue, CS Ng, P Xiang, H Liu, K Zhang… - Frontiers in molecular …, 2020 - frontiersin.org
Genetic analyses of patients with amyotrophic lateral sclerosis (ALS) have revealed a
strong association between mutations in genes encoding many RNA-binding proteins (RBPs), …
strong association between mutations in genes encoding many RNA-binding proteins (RBPs), …
[HTML][HTML] DHX36 enhances RIG-I signaling by facilitating PKR-mediated antiviral stress granule formation
JS Yoo, K Takahasi, CS Ng, R Ouda, K Onomoto… - PLoS …, 2014 - journals.plos.org
RIG-I is a DExD/H-box RNA helicase and functions as a critical cytoplasmic sensor for RNA
viruses to initiate antiviral interferon (IFN) responses. Here we demonstrate that another …
viruses to initiate antiviral interferon (IFN) responses. Here we demonstrate that another …
[HTML][HTML] Production of a dominant-negative fragment due to G3BP1 cleavage contributes to the disruption of mitochondria-associated protective stress granules during …
G Fung, CS Ng, J Zhang, J Shi, J Wong, P Piesik… - PloS one, 2013 - journals.plos.org
Stress granules (SGs) are dynamic cytosolic aggregates containing messenger ribonucleoproteins
and target poly-adenylated (A)-mRNA. A key component of SGs is Ras-GAP SH3 …
and target poly-adenylated (A)-mRNA. A key component of SGs is Ras-GAP SH3 …
Fueling type I interferonopathies: regulation and function of type I interferon antiviral responses
CS Ng, H Kato, T Fujita - Journal of Interferon & Cytokine Research, 2019 - liebertpub.com
In conjunction with the development of genome-wide technology, numerous studies have
revealed the importance of regulatory mechanisms to avoid the onset of autoimmunity. In this, …
revealed the importance of regulatory mechanisms to avoid the onset of autoimmunity. In this, …
[PDF][PDF] cGAS and DDX41-STING mediated intrinsic immunity spreads intercellularly to promote neuroinflammation in SOD1 ALS model
…, YC Xue, H Liu, T Furihata, EM Shankar, CS Ng - Iscience, 2022 - cell.com
Neuroinflammation exacerbates the progression of SOD1-driven amyotrophic lateral
sclerosis (ALS), although the underlying mechanisms remain largely unknown. Herein, we …
sclerosis (ALS), although the underlying mechanisms remain largely unknown. Herein, we …
Innate immune evasion mediated by picornaviral 3C protease: Possible lessons for coronaviral 3C‐like protease?
CS Ng, CC Stobart, H Luo - Reviews in Medical Virology, 2021 - Wiley Online Library
… Chen Seng Ng … Chen Seng Ng and Honglin Luo designed and outlined the review. Chen
Seng Ng prepared the initial manuscript and figures. Christopher C. Stobart prepared the …
Seng Ng prepared the initial manuscript and figures. Christopher C. Stobart prepared the …
[HTML][HTML] The papain-like protease of coronaviruses cleaves ULK1 to disrupt host autophagy
Y Mohamud, YC Xue, H Liu, CS Ng, A Bahreyni… - Biochemical and …, 2021 - Elsevier
The ongoing pandemic of COVID-19 alongside the outbreaks of SARS in 2003 and MERS
in 2012 underscore the significance to understand betacoronaviruses as a global health …
in 2012 underscore the significance to understand betacoronaviruses as a global health …
[HTML][HTML] Coxsackievirus type B3 is a potent oncolytic virus against KRAS-mutant lung adenocarcinoma
…, H Liu, T de Silva, YC Xue, Y Mohamud, CS Ng… - Molecular Therapy …, 2019 - cell.com
KRAS mutant (KRAS mut ) lung adenocarcinoma is a refractory cancer without available
targeted therapy. The current study explored the possibility to develop coxsackievirus type B3 (…
targeted therapy. The current study explored the possibility to develop coxsackievirus type B3 (…