Shp-2, a widely expressed cytoplasmic tyrosine phosphatase with two SH2 domains, is
believed to participate in signal relay downstream of growth factor receptors. We show here that …

1. ABSTRACT The Janus kinase (JAK)/signal transducer and activator of transcription (STAT)
pathway is crucial in controlling cellular activities in response to extracellular cytokines. …

The regulation and coordination of mitochondrial metabolism with hematopoietic stem cell (HSC)
self-renewal and differentiation is not fully understood. Here we report that depletion of …

Germline activating mutations of the protein tyrosine phosphatase SHP2 (encoded by PTPN11),
a positive regulator of the RAS signalling pathway 1 , are found in 50% of patients with …

Loss of LKB1 is associated with increased metastasis and poor prognosis in lung cancer,
but the development of targeted agents is in its infancy. Here we report that a glutaminolytic …

Cellular biological activities are tightly controlled by intracellular signaling processes initiated
by extracellular signals. Protein tyrosine phosphatases, which remove phosphate groups …

The tissue inhibitors of metalloproteinases (TIMPs) regulate matrix metalloproteinase activity
required for cell migration/invasion associated with cancer progression and angiogenesis. …

Cytokines and growth factors are important extracellular regulatory proteins. They exert their
biological functions through binding to their cognate receptors on the cell surface and …

Shp-1 and Shp-2 are cytoplasmic protein tyrosine phosphatases that contain two Src
homology 2 (SH2) domains. A negative regulatory role of Shp-1 in hematopoiesis has been …

Coagulation factor XII (FXII) deficiency is associated with decreased neutrophil migration,
but the mechanisms remain uncharacterized. Here, we examine how FXII contributes to the …