Genomic atlas of the proteome from brain, CSF and plasma prioritizes proteins implicated in neurological disorders
Understanding the tissue-specific genetic controls of protein levels is essential to uncover
mechanisms of post-transcriptional gene regulation. In this study, we generated a genomic …
mechanisms of post-transcriptional gene regulation. In this study, we generated a genomic …
Proteomics of brain, CSF, and plasma identifies molecular signatures for distinguishing sporadic and genetic Alzheimer's disease
Proteomic studies for Alzheimer’s disease (AD) are instrumental in identifying AD pathways
but often focus on single tissues and sporadic AD cases. Here, we present a proteomic study …
but often focus on single tissues and sporadic AD cases. Here, we present a proteomic study …
MicroRNA profiling reveals marker of motor neuron disease in ALS models
…, AJ Wegener, TS Hyman, C Yang… - Journal of …, 2017 - Soc Neuroscience
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder marked by
the loss of motor neurons (MNs) in the brain and spinal cord, leading to fatally debilitating …
the loss of motor neurons (MNs) in the brain and spinal cord, leading to fatally debilitating …
Ptm4tag: sharpening tag recommendation of stack overflow posts with pre-trained models
Stack Overflow is often viewed as one of the most influential Software Question & Answer (SQA)
websites, containing millions of programming-related questions and answers. Tags play …
websites, containing millions of programming-related questions and answers. Tags play …
[HTML][HTML] Mendelian randomization and genetic colocalization infer the effects of the multi-tissue proteome on 211 complex disease-related phenotypes
Background Human proteins are widely used as drug targets. Integration of large-scale
protein-level genome-wide association studies (GWAS) and disease-related GWAS has thus …
protein-level genome-wide association studies (GWAS) and disease-related GWAS has thus …
[PDF][PDF] Cell-type-specific profiling of alternative translation identifies regulated protein isoform variation in the mouse brain
Alternative translation initiation and stop codon readthrough in a few well-studied cases have
been shown to allow the same transcript to generate multiple protein variants. Because the …
been shown to allow the same transcript to generate multiple protein variants. Because the …
Aspect-based api review classification: How far can pre-trained transformer model go?
APIs (Application Programming Interfaces) are reusable software libraries and are building
blocks for modern rapid software development. Previous research shows that programmers …
blocks for modern rapid software development. Previous research shows that programmers …
The TMEM106B FTLD-protective variant, rs1990621, is also associated with increased neuronal proportion
Apart from amyloid β deposition and tau neurofibrillary tangles, Alzheimer's disease (AD) is
a neurodegenerative disorder characterized by neuronal loss and astrocytosis in the …
a neurodegenerative disorder characterized by neuronal loss and astrocytosis in the …
Provably superior accuracy in quantum stochastic modeling
In the design of stochastic models, there is a constant trade-off between model complexity
and accuracy. Here we prove that quantum models enable a more favorable trade-off. We …
and accuracy. Here we prove that quantum models enable a more favorable trade-off. We …
Post2vec: Learning distributed representations of Stack Overflow posts
Past studies have proposed solutions that analyze Stack Overflow content to help users find
desired information or aid various downstream software engineering tasks. A common step …
desired information or aid various downstream software engineering tasks. A common step …