Severe multidrug resistance has frequently compromised the therapeutic efficacy of one first-line
chemotherapeutic drug cisplatin. Here, we report cocktail polyprodrug nanoparticles (…

Cerebral small vessel disease (CSVD) represents a diverse cluster of cerebrovascular
diseases primarily affecting small arteries, capillaries, arterioles and venules. The diagnosis of …

Photoacoustic (PA) technology can transform light energy into acoustic wave, which can be
used for either imaging or therapy that depends on the power density of pulsed laser. Here, …

Microvessels of the blood-brain barrier (BBB) regulate transport into the brain. The highly
specialized brain microvascular endothelial cells, a major component of the BBB, express tight …

The blood–brain barrier (BBB) is the main obstacle to the effective delivery of therapeutic
agents to the brain, compromising treatment efficacy for a variety of neurological disorders. Intra…

Ischemic stroke is a major cause of disability and mortality worldwide, but effective restorative
treatments are very limited at present. Regenerative medicine research revealed that stem …

The fluorophores in the second near‐infrared (NIR‐II) biological window (1000 – 1700 nm)
show great application prospects in the fields of biology and optical communications. …

While carbon dots (C‐dots) have been extensively investigated pertaining to their fluorescent,
phosphorescent, electrochemiluminescent, optoelectronic, and catalytic features, their …

Hydrogel scaffolding of stem cells is a promising strategy to overcome initial cell loss and
manipulate cell function post‐transplantation. Matrix degradation is a requirement for …

As the majority of therapeutic agents do not cross the blood–brain barrier (BBB), transient
BBB opening (BBBO) is one strategy to enable delivery into the brain for effective treatment of …