A lzheimer's disease ( AD ) is a neurodegenerative disorder characterized by loss of memory
and cognitive abilities, and the appearance of amyloid plaques composed of the amyloid‐β …

Mitochondria-associated membranes (MAMs) are central microdomains that fine-tune
bioenergetics by the local transfer of calcium from the endoplasmic reticulum to the mitochondrial …

Tau is a protein that is highly enriched in neurons and was originally defined by its ability to
bind and stabilize microtubules. However, it is now becoming evident that the functions of tau …

We have synthesized a family of rhein–huprine hybrids to hit several key targets for Alzheimer’s
disease. Biological screening performed in vitro and in Escherichia coli cells has shown …

Alzheimer’s disease (AD) is an age-related neurodegenerative disorder associated with
progressive memory loss, severe dementia, and hallmark neuropathological markers, such as …

… Additionally, in Tg mice with deficient function of Wnt signaling we observed increased
number of senile plaques (Tapia-Rojas and Inestrosa, 2018), validating the in vitro studies that …

Alzheimer’s disease (AD) is a neurodegenerative disorder in which the amyloid-β (Aβ)
oligomers are a key factor in synaptic impairment and in spatial memory decline associated with …

Aging is a process characterized by cognitive impairment and mitochondrial dysfunction. In
neurons, these organelles are classified as synaptic and non-synaptic mitochondria …

Background L-methionine, the principal sulfur-containing amino acid in proteins, plays critical
roles in cell physiology as an antioxidant and in the breakdown of fats and heavy metals. …

Wnt/β-catenin signalling is an important pathway that regulates multiple biological processes,
including cell adhesion and determination of cell fate during animal development; in the …