User profiles for Cheryl A. Keller
 | Cheryl A. Keller, PhDThe Pennsylvania State University Verified email at psu.edu Cited by 7191 |
[HTML][HTML] Expanded encyclopaedias of DNA elements in the human and mouse genomes
…, F Pauli-Behn, BA Williams, A Mortazavi, CA Keller… - Nature, 2020 - nature.com
The human and mouse genomes contain instructions that specify RNAs and proteins and
govern the timing, magnitude, and cellular context of their production. To better delineate these …
govern the timing, magnitude, and cellular context of their production. To better delineate these …
[HTML][HTML] A comparative encyclopedia of DNA elements in the mouse genome
The laboratory mouse shares the majority of its protein-coding genes with humans, making
it the premier model organism in biomedical research, yet the two mammals differ in …
it the premier model organism in biomedical research, yet the two mammals differ in …
[HTML][HTML] An encyclopedia of mouse DNA elements (Mouse ENCODE)
To complement the human Encyclopedia of DNA Elements (ENCODE) project and to enable
a broad range of mouse genomics efforts, the Mouse ENCODE Consortium is applying the …
a broad range of mouse genomics efforts, the Mouse ENCODE Consortium is applying the …
Regulation of GABAA receptor trafficking, channel activity, and functional plasticity of inhibitory synapses
Neural inhibition in the brain is mainly mediated by ionotropic γ-aminobutyric acid type A (GABA
A ) receptors. Different subtypes of these receptors, distinguished by their subunit …
A ) receptors. Different subtypes of these receptors, distinguished by their subunit …
The γ2 subunit of GABAA receptors is a substrate for palmitoylation by GODZ
CA Keller, X Yuan, P Panzanelli, ML Martin… - Journal of …, 2004 - Soc Neuroscience
The neurotransmitter GABA activates heteropentameric GABA A receptors, which are
composed mostly of α, β, and γ2 subunits. Regulated membrane trafficking and subcellular …
composed mostly of α, β, and γ2 subunits. Regulated membrane trafficking and subcellular …
[HTML][HTML] Principles of regulatory information conservation between mouse and human
To broaden our understanding of the evolution of gene regulation mechanisms, we
generated occupancy profiles for 34 orthologous transcription factors (TFs) in human–mouse …
generated occupancy profiles for 34 orthologous transcription factors (TFs) in human–mouse …
Chromatin structure dynamics during the mitosis-to-G1 phase transition
Features of higher-order chromatin organization—such as A/B compartments, topologically
associating domains and chromatin loops—are temporarily disrupted during mitosis 1 , 2 . …
associating domains and chromatin loops—are temporarily disrupted during mitosis 1 , 2 . …
GODZ-mediated palmitoylation of GABAA receptors is required for normal assembly and function of GABAergic inhibitory synapses
Golgi-specific DHHC (Asp-His-His-Cys) zinc finger protein (GODZ) is a DHHC family palmitoyl
acyltransferase that is implicated in palmitoylation and regulated trafficking of diverse …
acyltransferase that is implicated in palmitoylation and regulated trafficking of diverse …
Domain-focused CRISPR screen identifies HRI as a fetal hemoglobin regulator in human erythroid cells
…, CJ Face, DF Posocco, O Abdulmalik, CA Keller… - Science, 2018 - science.org
Increasing fetal hemoglobin (HbF) levels in adult red blood cells provides clinical benefit to
patients with sickle cell disease and some forms of β-thalassemia. To identify potentially …
patients with sickle cell disease and some forms of β-thalassemia. To identify potentially …
[PDF][PDF] The BET protein BRD2 cooperates with CTCF to enforce transcriptional and architectural boundaries
Bromodomain and extraterminal motif (BET) proteins are pharmacologic targets for the treatment
of diverse diseases, yet the roles of individual BET family members remain unclear. We …
of diverse diseases, yet the roles of individual BET family members remain unclear. We …