Inhibitors against the p110δ isoform of phosphoinositide-3-OH kinase (PI(3)K) have shown
remarkable therapeutic efficacy in some human leukaemias 1 , 2 . As p110δ is primarily …

Increasing chemotherapy delivery to tumors, while enhancing drug uptake and reducing side
effects, is a primary goal of cancer research. In mouse and human cancer models in vivo, …

Venous malformations (VMs) are painful and deforming vascular lesions composed of dilated
vascular channels, which are present from birth. Mutations in the TEK gene, encoding the …

Loss of the kinase MAP3K4 causes mouse embryonic gonadal sex reversal due to reduced
expression of the testis-determining gene, Sry. However, because of widespread expression …

… Library of Congress Cataloging-in-Publication Data Scudamore, Cheryl L., author. A
practical guide to the histology of the mouse/Cheryl L. Scudamore. p.; cm. …

Mucosal mast cells undergo hYPerPlasia in a variety of inflammatory bowel diseases including
nematode infection in man and animals. The intra-epithelial localization of these cells …

Utilizing T cells expressing chimeric antigen receptors (CARs) to identify and attack solid
tumors has proven challenging, in large part because of the lack of tumor-specific targets to …

Disruption of the centromere protein J gene, CENPJ (CPAP, MCPH6, SCKL4), which is a
highly conserved and ubiquitiously expressed centrosomal protein, has been associated with …

In contrast to the class I phosphoinositide 3-kinases (PI3Ks), the organismal roles of the
kinase activity of the class II PI3Ks are less clear. Here, we report that class II PI3K-C2β kinase-…

C57BL/6N (B6N) is becoming the standard background for genetic manipulation of the
mouse genome. The B6N, whose genome is very closely related to the reference C57BL/6J …