During the COVID-19 pandemic, an at-home laboratory program was created and implemented
for a section of the general chemistry course at the University of Southern California. The …

An exact and efficient new method to simulate dynamics in dissipative quantum systems is
presented. A stochastic Liouville equation, deduced from Feynman and Vernon’s path-…

Base stacking is a key determinant of nucleic acid structures, but the precise origin of the
thermodynamic driving force behind the stacking of nucleobases remains open. The rather mild …

Activation-induced deoxycytidine deaminase (AID) generates antibody diversity in B cells
by initiating somatic hypermutation (SHM) and class-switch recombination (CSR) during …

We formulated a master equation-based mathematical model to analyze random scanning
and catalysis for enzymes that act on single-stranded DNA (ssDNA) substrates. Catalytic …

Homologs of the mutagenic Escherichia coli DNA polymerase V (pol V) are encoded by
numerous pathogens and mobile elements. We have used Rum pol (RumA′ 2 B), from the …

Mutagenic translesion DNA polymerase V (UmuD′ 2 C) is induced as part of the DNA
damage-induced SOS response in Escherichia coli, and is subjected to multiple levels of …

Functional RNAs can fold into intricate structures using a number of different secondary and
tertiary structural motifs. Many factors contribute to the overall free energy of the target fold. …

1Mechanical and Aerospace Engineering, The Ohio State University, Columbus, OH, USA,
2Comprehensive Cancer Center, The Ohio State University, Columbus, OH, USA, …

Base pairing complementarity is central to DNA function. G·C and A·T pair specificity is thought
to originate from the different number of hydrogen bonds the pairs make. Quantifying how …