Amyloids are insoluble fibrillar protein deposits with an underlying cross-β structure initially
discovered in the context of human diseases. However, it is now clear that the same fibrillar …

The functional amyloid state of proteins has in recent years garnered much attention for its
role in serving crucial and diverse biological roles. Amyloid is a protein fold characterised by …

Many critical biological processes take place at hydrophobic:hydrophilic interfaces, and a
wide range of organisms produce surface-active proteins and peptides that reduce surface …

Parkinson’s disease (PD) is a progressive, chronic disease characterized by dyskinesia,
rigidity, instability, and tremors. The disease is defined by the presence of Lewy bodies, which …

Cell death signalling pathways contribute to tissue homeostasis and provide innate
protection from infection. Adaptor proteins such as receptor-interacting serine/threonine-protein …

The self-association of proteins to form amyloid fibrils has been implicated in the
pathogenesis of a number of diseases including Alzheimer's, Parkinson's, and Creutzfeldt-Jakob …

α-Synuclein is the major component of the intracellular Lewy body inclusions present in
Parkinson disease (PD) neurons. PD involves the loss of dopaminergic neurons in the …

Amyloid beta (Aβ) peptide is the major constituent of the extracellular amyloid plaques
deposited in the brains of Alzheimer's disease patients and is central to the pathogenic pathway …

The interaction of the small (140 amino acid) protein, α-synuclein (αS), with Cu 2+ has been
proposed to play a role in Parkinson’s disease (PD). While some insight from truncated …

The murine cytomegalovirus protein M45 protects infected mouse cells from necroptotic death
and, when heterologously expressed, can protect human cells from necroptosis induced …