Ischemia-reperfusion injury is associated with serious clinical manifestations, including
myocardial hibernation, acute heart failure, cerebral dysfunction, gastrointestinal dysfunction, …

Although pyroptosis is critical for macrophages against pathogen infection, its role and
mechanism in cancer cells remains unclear. PD-L1 has been detected in the nucleus, with …

The epithelial–mesenchymal transition (EMT) has recently been linked to stem cell phenotype
1 , 2 . However, the molecular mechanism underlying EMT and regulation of stemness …

Extracellular interaction between programmed death ligand-1 (PD-L1) and programmed cell
death protein-1 (PD-1) leads to tumour-associated immune escape. Here we show that the …

Purpose: To explore whether a cross-talk exists between PARP inhibition and PD-L1/PD-1
immune checkpoint axis, and determine whether blockade of PD-L1/PD-1 potentiates PARP …

To clarify the influence of gender on sympathetic and parasympathetic control of heart rate
in middle-aged subjects and on the subsequent aging process, heart rate variability (HRV) …

In recent decades, chemotherapies targeting apoptosis have emerged and demonstrated
remarkable achievements. However, emerging evidence has shown that chemoresistance is …

This study employed problem‐based learning for project work in a year 9 biology class. The
purpose of the study was to investigate (a) students' inspirations for their self‐generated …

Sponge remains have been identified in the Early Vendian Doushantuo phosphate deposit
in central Guizhou (South China), which has an age of ∼580 million years ago. Their …

Pro-inflammatory cytokines produced in the tumor microenvironment lead to eradication of
anti-tumor immunity and enhanced tumor cell survival. In the current study, we identified …