Osteoarthritis as a disease of the cartilage pericellular matrix
Osteoarthritis is a painful joint disease characterized by progressive degeneration of the
articular cartilage as well as associated changes to the subchondral bone, synovium, and …
articular cartilage as well as associated changes to the subchondral bone, synovium, and …
Genome engineering for personalized arthritis therapeutics
SS Adkar, JM Brunger, VP Willard, CL Wu… - Trends in molecular …, 2017 - cell.com
Arthritis represents a family of complex joint pathologies responsible for the majority of
musculoskeletal conditions. Nearly all diseases within this family, including osteoarthritis, …
musculoskeletal conditions. Nearly all diseases within this family, including osteoarthritis, …
[HTML][HTML] Single cell transcriptomic analysis of human pluripotent stem cell chondrogenesis
The therapeutic application of human induced pluripotent stem cells (hiPSCs) for cartilage
regeneration is largely hindered by the low yield of chondrocytes accompanied by …
regeneration is largely hindered by the low yield of chondrocytes accompanied by …
Intra-articular delivery of purified mesenchymal stem cells from C57BL/6 or MRL/MpJ superhealer mice prevents posttraumatic arthritis
Joint injury dramatically enhances the onset of osteoarthritis (OA) and is responsible for an
estimated 12% of OA. Posttraumatic arthritis (PTA) is especially common after intra-articular …
estimated 12% of OA. Posttraumatic arthritis (PTA) is especially common after intra-articular …
Dietary fatty acid content regulates wound repair and the pathogenesis of osteoarthritis following joint injury
Objective The mechanisms linking obesity and osteoarthritis (OA) are not fully understood
and have been generally attributed to increased weight, rather than metabolic or inflammatory …
and have been generally attributed to increased weight, rather than metabolic or inflammatory …
[HTML][HTML] Cartilage-specific knockout of the mechanosensory ion channel TRPV4 decreases age-related osteoarthritis
Osteoarthritis (OA) is a progressive degenerative disease of articular cartilage and surrounding
tissues, and is associated with both advanced age and joint injury. Biomechanical factors …
tissues, and is associated with both advanced age and joint injury. Biomechanical factors …
Diet-induced obesity alters the differentiation potential of stem cells isolated from bone marrow, adipose tissue and infrapatellar fat pad: the effects of free fatty acids
Materials and Methods: Bone marrow-derived mesenchymal stem cells (MSCs), subcutaneous
adipose-derived stem cells (sqASCs) and infrapatellar fat pad-derived stem cells (IFP …
adipose-derived stem cells (sqASCs) and infrapatellar fat pad-derived stem cells (IFP …
Conditional macrophage depletion increases inflammation and does not inhibit the development of osteoarthritis in obese macrophage Fas‐induced apoptosis …
… Wu had full access to all of the data in the study and takes responsibility for the integrity of
the … Wu CL, Little D. Animal models of meniscal injury in posttraumatic arthritis. In: Olson SA, …
the … Wu CL, Little D. Animal models of meniscal injury in posttraumatic arthritis. In: Olson SA, …
Synovial fibroblasts assume distinct functional identities and secrete R-spondin 2 in osteoarthritis
…, E Knight, D Farmer, AA Samani, CL Wu… - Annals of the …, 2023 - ard.bmj.com
Objectives Synovium is acutely affected following joint trauma and contributes to post-traumatic
osteoarthritis (PTOA) progression. Little is known about discrete cell types and molecular …
osteoarthritis (PTOA) progression. Little is known about discrete cell types and molecular …
Physiologic and pathologic effects of dietary free fatty acids on cells of the joint
Fatty acids (FAs) are potent organic compounds that not only can be used as an energy source
during nutrient deprivation but are also involved in several essential signaling cascades …
during nutrient deprivation but are also involved in several essential signaling cascades …