Anatomic properties of myocardial bridge predisposing to myocardial infarction

…, R Shimokawa, K Shimada, C Nishimura… - Circulation, 2009 - Am Heart Assoc
Background— A myocardial bridge (MB) that partially covers the course of the left anterior
descending coronary artery (LAD) sometimes causes myocardial ischemia, primarily because …

Anti-Hypertensive Effect of γ-Aminobutyric Acid (GABA)-Rich Chlorella on High-Normal Blood Pressure and Borderline Hypertension in Placebo-Controlled Double …

M Shimada, T Hasegawa, C Nishimura… - Clinical and …, 2009 - Taylor & Francis
The anti-hypertensive effect of GABA-rich Chlorella was studied after oral administration for
12 weeks in the subjects with high-normal blood pressure and borderline hypertension in the …

Identification of native and non-native structure in kinetic folding intermediates of apomyoglobin

C Nishimura, HJ Dyson, PE Wright - Journal of molecular biology, 2006 - Elsevier
Site-directed mutagenesis has been used to probe the interactions that stabilize the equilibrium
and burst phase kinetic intermediates formed by apomyoglobin. Nine bulky hydrophobic …

Hierarchical folding mechanism of apomyoglobin revealed by ultra-fast H/D exchange coupled with 2D NMR

T Uzawa, C Nishimura, S Akiyama… - Proceedings of the …, 2008 - National Acad Sciences
The earliest steps in the folding of proteins are complete on an extremely rapid time scale
that is difficult to access experimentally. We have used rapid-mixing quench-flow methods to …

Conservation of folding pathways in evolutionarily distant globin sequences

C Nishimura, S Prytulla, H Jane Dyson… - Nature structural …, 2000 - nature.com
To test the hypothesis that the folding pathways of evolutionarily related proteins with similar
three-dimensional structures but widely different sequences should be similar, the folding …

[HTML][HTML] Purification and characterization of N-β-alanyl-5-S-glutathionyl-3, 4-dihydroxyphenylalanine, a novel antibacterial substance of Sarcophaga peregrina (flesh …

JY Leem, C Nishimura, S Kurata, I Shimada… - Journal of Biological …, 1996 - ASBMB
We purified a novel antibacterial substance from immunized adult Sarcophaga and determined
its molecular structure to be N-β-alanyl-5-S-glutathionyl-3,4-dihydroxyphenylalanine (5-S…

Ability of optical coherence tomography–determined ganglion cell complex thickness to total retinal thickness ratio to diagnose glaucoma

…, R Kita, A Takeyama, S Takagi, C Nishimura… - Journal of …, 2013 - journals.lww.com
Purpose: To evaluate the usefulness of the spectral-domain optical coherence tomography (SD
OCT)–determined ganglion cell complex thickness to total retinal thickness ratio (G/T …

The apomyoglobin folding pathway revisited: structural heterogeneity in the kinetic burst phase intermediate

C Nishimura, HJ Dyson, PE Wright - Journal of molecular biology, 2002 - Elsevier
Extensive analysis of accurate quench-flow hydrogen exchange results indicates that the
burst phase kinetic intermediate in the folding of apomyoglobin (apoMb) from urea is …

Enhanced picture of protein-folding intermediates using organic solvents in H/D exchange and quench-flow experiments

C Nishimura, HJ Dyson… - Proceedings of the …, 2005 - National Acad Sciences
Hydrogen/deuterium exchange followed by trapping of the labeled species in the aprotic
solvent DMSO has been used to elucidate structure in both the burst-phase molten globule-…

Effect of salts on the stability and folding of staphylococcal nuclease

C Nishimura, VN Uversky, AL Fink - Biochemistry, 2001 - ACS Publications
The stability and folding kinetics of wild-type and a mutant staphylococcal nuclease (SNase)
at neutral pH are significantly perturbed by the presence of moderate to high concentrations …