Halloysite is a nanostructured clay mineral with hollow tubular structure, which has recently
found an important role as delivery system for drugs or other active molecules. One of these …

Human induced pluripotent stem cells (iPSCs) are used to generate models of human diseases
that recapitulate the pathogenic process as it occurs in affected cells. Many differentiated …

The diverse gut microbiota, which is associated with mucosal health and general wellbeing,
maintains gut-associated lymphoid tissues (GALT) in a chronically activated state, including …

Clinical trials in rare diseases as Friedreich ataxia (FRDA) offer special challenges, particularly
when multiple treatments become ready for clinical testing. Regulatory health authorities …

Friedreich ataxia is an autosomal recessive multisystem disorder with prominent neurological
manifestations and cardiac involvement. The disease is caused by large GAA expansions …

Epigenetic silencing in Friedreich ataxia (FRDA), induced by an expanded GAA triplet-repeat
in intron 1 of the FXN gene, results in deficiency of the mitochondrial protein, frataxin. A …

Gut-associated lymphoid tissue (GALT) is organised lymphoid tissue that is chronically
activated by the intestinal microbiota. It generates the IgA response that is critical for intestinal …

FRDA is the most common autosomal recessive inherited ataxia in Caucasians, accounting
for half of the inherited degenerative ataxias and for three-quarters of those with onset before …

Nel confrontare la Convenzione dell’Unesco e la Convenzione Europea del Paesaggio è
possibile evidenziare una differenza sostanziale nell’interpretazione del paesaggio. Il primo …

Il crescente interesse nel campo delle nanotecnologie ha portato, accanto alla sviluppo di
carriers sintetici, anche alla ricerca e allo studio di materiali nanostrutturati presenti in natura. L…