Lifestyle factors are responsible for a considerable portion of cancer incidence worldwide,
but credible estimates from the World Health Organization and the International Agency for …

Genome instability is a prerequisite for the development of cancer. It occurs when genome
maintenance systems fail to safeguard the genome’s integrity, whether as a consequence of …

An emerging area in environmental toxicology is the role that chemicals and chemical mixtures
have on the cells of the human immune system. This is an important area of research that …

The DNA damage response (DDR) is activated upon DNA damage generation to promote
DNA repair and inhibit cell cycle progression in the presence of a lesion. Cellular senescence …

Potentially carcinogenic compounds may cause cancer through direct DNA damage or
through indirect cellular or physiological effects. To study possible carcinogens, the fields of …

Telomerase canonical activity at telomeres prevents telomere shortening, allowing
chromosome stability and cellular proliferation. To perform this task, the catalytic subunit (telomerase …

Environmental contributions to cancer development are widely accepted, but only a fraction
of all pertinent exposures have probably been identified. Traditional toxicological …

Background In vertebrates, tandem arrays of TTAGGG hexamers are present at both
telomeres and intrachromosomal sites (interstitial telomeric sequences (ITSs)). We previously …

Short blocks of telomeric-like DNA (Interstitial Telomeric Sequences, ITSs) are found far
from chromosome ends. We addressed the question as to how such sequences arise by …

Several lines of evidence indicate that telomere shortening duringin vitroaging of human
somatic cells plays a causal role in cellular senescence. A critical telomere length seems to be …