Stat3 in different cells (5). For instance, part of the mechanism by which Stat3 stimulates B
cell proliferation is through inhibition of apoptosis, a function mediated by induction of the …

Propagation of mouse embryonic stem (ES) cells in vitro requires exogenous leukemia
inhibitory factor (LIF) or related cytokines. Potential downstream effectors of the LIF signal in ES …

Dengue haemorrhagic fever and dengue shock syndrome, the most severe responses to
dengue virus (DV) infection, are characterized by plasma leakage (due to increased vascular …

IFNs protect from virus infection by inducing an antiviral state and by modulating the immune
response. Using mice deficient in multiple aspects of IFN signaling, we found that type I and …

STAT5 is activated in a broad spectrum of human hematologic malignancies. We addressed
whether STAT5 activation is necessary for the myelo- and lymphoproliferative disease …

STAT3 has been described as an essential component of G-CSF-driven cell proliferation
and granulopoiesis. This notion was tested by conditional gene ablation in transgenic mice. …

NK cell functions were examined in mice with a targeted mutation of the STAT1 gene, an
essential mediator of IFN signaling. Mice deficient in STAT1 displayed impaired basal NK …

Type I IFNs are crucial cytokines of innate immunity for combating viral infections. Signaling
through type I IFN receptors triggers the activation of STAT proteins, including STAT1, STAT2…

Lymphocytes derived from mice deficient in STAT1 showed reduced apoptosis and enhanced
proliferation in vitro. To understand the involvement of STAT1 in the observed reduction in …

Evidence is accumulating for the existence of a signal transducer and activator of transcription
2 (STAT2)/interferon regulatory factor 9 (IRF9)-dependent, STAT1-independent interferon …