Adult stem cells reside in specialized niches where they receive environmental cues to
maintain tissue homeostasis. In mammals, the stem cell niche within hair follicles is home to …

Hair production is fueled by stem cells (SCs), which transition between cyclical bouts of rest
and activity. Here, we explore why hair growth wanes with age. We show that aged hair …

Mutation of SMARCA4 (BRG1), the ATPase of BAF (mSWI/SNF) and PBAF complexes,
contributes to a range of malignancies and neurologic disorders. Unfortunately, the effects of …

Genes that drive the proliferation, survival, invasion and metastasis of malignant cells have
been identified for many human cancers 1 , 2 , 3 – 4 . Independent studies have identified …

We establish the first human forward genetic modeling of a commonly mutated tumor
suppressor gene, ARID1A . Our study integrates diverse modalities including CRISPR/Cas9 …

Dendritic arborization is a critical neuronal differentiation process. Here, we demonstrate that
syndecan-2 (Sdc2), a synaptic heparan sulfate proteoglycan that triggers dendritic filopodia …

The resolution and formation of facultative heterochromatin are essential for development,
reprogramming, and oncogenesis. The mechanisms underlying these changes are poorly …

Mammalian SWI/SNF (BAF) chromatin remodelers play dosage-sensitive roles in many human
malignancies and neurologic disorders. The gene encoding the BAF subunit actin-like 6a …

Autophagy is a catabolic membrane-trafficking mechanism conserved in all eukaryotic cells.
In addition to the nonselective transport of bulk cytosol, autophagy is responsible for efficient …

Background: Attention deficit and hyperactivity disorder (ADHD) is the most common
neurobehavioral disorder of childhood. ADHD has been shown to persist into adulthood in 30%–70…