User profiles for Chloe H. Lee
 | Chloe H. LeeOxford University Verified email at rdm.ox.ac.uk Cited by 368 |
Diagnostics and correction of batch effects in large‐scale proteomic studies: a tutorial
Advancements in mass spectrometry‐based proteomics have enabled experiments encompassing
hundreds of samples. While these large sample sets deliver much‐needed statistical …
hundreds of samples. While these large sample sets deliver much‐needed statistical …
[HTML][HTML] In silico identification of vaccine targets for 2019-nCoV
Background: The newly identified coronavirus known as 2019-nCoV has posed a serious
global health threat. According to the latest report (18-February-2020), it has infected more …
global health threat. According to the latest report (18-February-2020), it has infected more …
[HTML][HTML] Potential CD8+ T cell cross-reactivity against SARS-CoV-2 conferred by other coronavirus strains
While individuals infected with coronavirus disease 2019 (COVID-19) manifested a broad
range in susceptibility and severity to the disease, the pre-existing immune memory to related …
range in susceptibility and severity to the disease, the pre-existing immune memory to related …
[HTML][HTML] Predicting cross-reactivity and antigen specificity of T cell receptors
Adaptive immune recognition is mediated by specific interactions between heterodimeric T
cell receptors (TCRs) and their cognate peptide-MHC (pMHC) ligands, and the methods to …
cell receptors (TCRs) and their cognate peptide-MHC (pMHC) ligands, and the methods to …
High-resolution profiling of MHC II peptide presentation capacity reveals SARS-CoV-2 CD4 T cell targets and mechanisms of immune escape
FJ Obermair, F Renoux, S Heer, CH Lee… - Science …, 2022 - science.org
Understanding peptide presentation by specific MHC alleles is fundamental for controlling
physiological functions of T cells and harnessing them for therapeutic use. However, …
physiological functions of T cells and harnessing them for therapeutic use. However, …
Evaluating performance of existing computational models in predicting CD8+ T cell pathogenic epitopes and cancer neoantigens
T cell recognition of a cognate peptide–major histocompatibility complex (pMHC) presented
on the surface of infected or malignant cells is of the utmost importance for mediating robust …
on the surface of infected or malignant cells is of the utmost importance for mediating robust …
HLA‐dependent variation in SARS‐CoV‐2 CD8 + T cell cross‐reactivity with human coronaviruses
The conditions and extent of cross‐protective immunity between severe acute respiratory
syndrome coronavirus 2 (SARS‐CoV‐2) and common‐cold human coronaviruses (HCoVs) …
syndrome coronavirus 2 (SARS‐CoV‐2) and common‐cold human coronaviruses (HCoVs) …
A systems approach evaluating the impact of SARS-CoV-2 variant of concern mutations on CD8+ T cell responses
T cell recognition of SARS-CoV-2 antigens after vaccination and/or natural infection has
played a central role in resolving SARS-CoV-2 infections and generating adaptive immune …
played a central role in resolving SARS-CoV-2 infections and generating adaptive immune …
[HTML][HTML] A robust deep learning workflow to predict CD8+ T-cell epitopes
Background T-cells play a crucial role in the adaptive immune system by triggering
responses against cancer cells and pathogens, while maintaining tolerance against self-antigens, …
responses against cancer cells and pathogens, while maintaining tolerance against self-antigens, …
[HTML][HTML] To what extent does MHC binding translate to immunogenicity in humans?
The ability of T-cells to distinguish between self vs foreign or mutated peptides plays a
critical role in cancer, inflammatory and autoimmune diseases. How this balance between T-cell …
critical role in cancer, inflammatory and autoimmune diseases. How this balance between T-cell …