The heart is the first major organ to develop during embryogenesis and must receive proper
spatiotemporal signaling for proper development. Failure of proper signaling between the …

RBFOX2, which has a well-established role in alternative splicing, is linked to heart diseases.
However, it is unclear whether RBFOX2 has other roles in RNA processing that can …

Forkhead box P3 (FOXP3) is the master fate-determining transcription factor in regulatory T (Treg)
cells and is essential for their development, function and homeostasis. Mutations in …

Over the last decade, our understanding of spliceosome structure and function has significantly
improved, refining the study of the impact of dysregulated splicing on human disease. As …

Congenital heart disease (CHD) is a leading cause of death in children <1 year of age.
Despite intense effort in the last 10 years, most CHDs (~70%) still have an unknown etiology. …

Genes associated with increased susceptibility to multiple sclerosis (MS) have been identified,
but their functions are incompletely understood. One of these genes codes for the RNA …

Three-prime untranslated regions (3′UTRs) of metazoan messenger RNAs (mRNAs) contain
numerous regulatory elements, yet remain largely uncharacterized. Using polyA capture, 3…

This paper clarifies the competitive advantage of Richemont in comparison to LVMH
particularly from the angle of portfolio strategy. Unlike LVMH, limited numbers of people know …

Methods: A total of 7250 participants aged 30 years and older from randomly selected 232
census areas, both rural and urban, throughout Japan were followed from 1980 to 2004. We …

Generation of chimeric antigen receptor (CAR) T cells from pluripotent stem cells (PSCs)
will enable advances in cancer immunotherapy. Understanding how CARs affect T cell …