User profiles for Chong Lek Koh

Chong-lek Koh

Gene Express Sdn Bhd
Verified email at geneexpress.com
Cited by 4219

[HTML][HTML] Plant-derived natural products as sources of anti-quorum sensing compounds

…, CK Sam, WF Yin, LY Tan, T Krishnan, YM Chong… - Sensors, 2013 - mdpi.com
Quorum sensing is a system of stimuli and responses in relation to bacterial cell population
density that regulates gene expression, including virulence determinants. Consequently, …

[HTML][HTML] Quorum quenching revisited—from signal decays to signalling confusion

KW Hong, CL Koh, CK Sam, WF Yin, KG Chan - Sensors, 2012 - mdpi.com
In a polymicrobial community, while some bacteria are communicating with neighboring
cells (quorum sensing), others are interrupting the communication (quorum quenching), thus …

[HTML][HTML] Multi-platform discovery of haplotype-resolved structural variation in human genomes

…, C Chen, X Chen, CS Chin, Z Chong… - Nature …, 2019 - nature.com
The incomplete identification of structural variants (SVs) from whole-genome sequencing
data limits studies of human genetic diversity and disease association. Here, we apply a suite …

[HTML][HTML] Isolation of Nipah virus from Malaysian Island flying-foxes

KB Chua, CL Koh, PS Hooi, KF Wee, JH Khong… - Microbes and …, 2002 - Elsevier
In late 1998, Nipah virus emerged in peninsular Malaysia and caused fatal disease in domestic
pigs and humans and substantial economic loss to the local pig industry. Surveillance of …

[HTML][HTML] Characterization of N-acylhomoserine lactone-degrading bacteria associated with the Zingiber officinale (ginger) rhizosphere: Co-existence of quorum quenching and quorum …

…, K Mathee, CK Sam, SR Chhabra, M Cámara, CL Koh… - BMC microbiology, 2011 - Springer
Background Cell-to-cell communication (quorum sensing (QS)) co-ordinates bacterial behaviour
at a population level. Consequently the behaviour of a natural multi-species community …

Pseudomonas aeruginosa AmpR Is a Global Transcriptional Factor That Regulates Expression of AmpC and PoxB β-Lactamases, Proteases, Quorum Sensing, and …

…, SD Indulkar, A Del Puerto, CL Koh… - Antimicrobial agents …, 2005 - Am Soc Microbiol
In members of the family Enterobacteriaceae, ampC, which encodes a β-lactamase, is
regulated by an upstream, divergently transcribed gene, ampR. However, in Pseudomonas …

Malabaricone C from Myristica cinnamomea Exhibits Anti-Quorum Sensing Activity

YM Chong, WF Yin, CY Ho, MR Mustafa… - Journal of natural …, 2011 - ACS Publications
A methanol-soluble extract of the bark of Myristica cinnamomea was found to exhibit anti-quorum
sensing activity, and subsequent bioassay-guided isolation led to the identification of …

Epidemiologic analysis of sporadic Salmonella typhi isolates and those from outbreaks by pulsed-field gel electrophoresis

…, YM Cheong, S Puthucheary, CL Koh… - Journal of Clinical …, 1994 - Am Soc Microbiol
Pulsed-field gel electrophoresis (PFGE) was used to compare and analyze 158 isolates of
Salmonella typhi from five well-defined outbreaks of typhoid fever in Malaysia and also …

A novel medium for the isolation of N-acylhomoserine lactone-degrading bacteria

…, WF Yin, CK Sam, CL Koh - Journal of Industrial …, 2009 - academic.oup.com
A novel chemically defined medium, named KG medium, supplemented with N-3-oxo-hexanoylhomoserine
lactone (3-oxo-C6-HSL), an acylhomoserine lactone (AHL) used as …

[HTML][HTML] N-Acyl Homoserine Lactone Production by Klebsiella pneumoniae Isolated from Human Tongue Surface

WF Yin, K Purmal, S Chin, XY Chan, CL Koh, CK Sam… - Sensors, 2012 - mdpi.com
Bacteria communicate by producing quorum sensing molecules called autoinducers, which
include autoinducer-1, an N-hexanoyl homoserine lactone (AHL), and autoinducer-2. …