Dual mechanisms of CYP3A protein regulation by proinflammatory cytokine stimulation in primary hepatocyte cultures
Whereas many cytochrome P450 enzymes are transcriptionally suppressed by inflammatory
stimuli, down-regulation of CYP2B protein by the inflammatory cytokine interleukin (IL)-1β is …
stimuli, down-regulation of CYP2B protein by the inflammatory cytokine interleukin (IL)-1β is …
[HTML][HTML] Nitric oxide-dependent proteasomal degradation of cytochrome P450 2B proteins
CM Lee, BY Kim, L Li, ET Morgan - Journal of biological chemistry, 2008 - ASBMB
Exposure to inflammatory agents or cytokines causes the suppression of cytochrome P450 (CYP)
enzyme activities and expression in liver and primary hepatocyte cultures. We showed …
enzyme activities and expression in liver and primary hepatocyte cultures. We showed …
Regulation of cytochrome P450 enzyme activity and expression by nitric oxide in the context of inflammatory disease
Many hepatic cytochrome P450 enzymes and their associated drug metabolizing activities
are down-regulated in disease states, and much of this has been associated with …
are down-regulated in disease states, and much of this has been associated with …
Roles of nitric oxide in inflammatory downregulation of human cytochromes P450
AE Aitken, CM Lee, ET Morgan - Free Radical Biology and Medicine, 2008 - Elsevier
The purpose of this study was to determine the role of nitric oxide (NO) in the downregulation
of human cytochrome P450 (CYP) enzymes and mRNAs by an inflammatory stimulus in …
of human cytochrome P450 (CYP) enzymes and mRNAs by an inflammatory stimulus in …
Modulation of hepatic cytochrome P450s by Citrobacter rodentium infection in interleukin-6-and interferon-γ-null mice
BA Nyagode, CM Lee, ET Morgan - Journal of Pharmacology and …, 2010 - ASPET
After infection with Citrobacter rodentium, murine hepatic cytochrome P450 (P450) mRNAs
are selectively regulated. Several serum proinflammatory cytokines are elevated, the most …
are selectively regulated. Several serum proinflammatory cytokines are elevated, the most …
Selective role for tumor necrosis factor-α, but not interleukin-1 or Kupffer cells, in down-regulation of CYP3A11 and CYP3A25 in livers of mice infected with a …
RD Kinloch, CM Lee, N van Rooijen… - Biochemical …, 2011 - Elsevier
Hepatic cytochrome P450 (P450) gene and protein expression are modulated during
inflammation and infection. Oral infection of C57BL/6 mice with Citrobacter rodentium produces …
inflammation and infection. Oral infection of C57BL/6 mice with Citrobacter rodentium produces …
Nitric oxide-regulated proteolysis of human CYP2B6 via the ubiquitin-proteasome system
CM Lee, S Tripathi, ET Morgan - Free Radical Biology and Medicine, 2017 - Elsevier
We showed previously that rat cytochrome P450 CYP2B1 undergoes NO-dependent
proteasomal degradation in response to inflammatory stimuli, and that the related human enzyme …
proteasomal degradation in response to inflammatory stimuli, and that the related human enzyme …
Metabolic reprograming and increased inflammation by cadmium exposure following early-life respiratory syncytial virus infection: the involvement of protein S …
Early-life respiratory syncytial virus (RSV) infection (eRSV) is one of the leading causes of
serious pulmonary disease in children. eRSV is associated with higher risk of developing …
serious pulmonary disease in children. eRSV is associated with higher risk of developing …
Hepatic cytochrome P450s, phase II enzymes and nuclear receptors are downregulated in a Th2 environment during Schistosoma mansoni infection
SM Mimche, BA Nyagode, MD Merrell, CM Lee… - Drug Metabolism and …, 2014 - ASPET
Inflammation and infection downregulate the activity and expression of cytochrome P450s (P450s)
and other drug metabolizing enzymes (DMEs) involved in hepatic drug clearance. …
and other drug metabolizing enzymes (DMEs) involved in hepatic drug clearance. …
Metabolism and action of proteasome inhibitors in primary human hepatocytes
Proteasome inhibitors are important tools for studying the roles of the proteasome in cellular
processes. In this study, we observed that the proteasome inhibitors N-benzoyloxycarbonyl (…
processes. In this study, we observed that the proteasome inhibitors N-benzoyloxycarbonyl (…