User profiles for Chringma Sherpa
 | Chringma SherpaNational Cancer Institute, NIH, Frederick, MD Verified email at nih.gov Cited by 412 |
[PDF][PDF] Isolation and characterization of antibacterial actinomycetes from soil samples of Kalapatthar, Mount Everest Region
TD Gurung, C Sherpa, VP Agrawal… - Nepal Journal of science …, 2009 - lib.icimod.org
Seventy-nine Actinomycetes were isolated from soils of Kalapatthar (5545m), Mount Everest
region. Twenty seven (34.18%) of the isolates showed an antibacterial activity against at …
region. Twenty seven (34.18%) of the isolates showed an antibacterial activity against at …
The HIV-1 Rev response element (RRE) adopts alternative conformations that promote different rates of virus replication
C Sherpa, JW Rausch, SFJ Le Grice… - Nucleic acids …, 2015 - academic.oup.com
The HIV Rev protein forms a complex with a 351 nucleotide sequence present in unspliced
and incompletely spliced human immunodeficiency virus (HIV) mRNAs, the Rev response …
and incompletely spliced human immunodeficiency virus (HIV) mRNAs, the Rev response …
Structural characterization of maternally expressed gene 3 RNA reveals conserved motifs and potential sites of interaction with polycomb repressive complex 2
C Sherpa, JW Rausch, SFJ Le Grice - Nucleic acids research, 2018 - academic.oup.com
Long non-coding RNAs (lncRNAs) have emerged as key players in gene regulation.
However, our incomplete understanding of the structure of lncRNAs has hindered molecular …
However, our incomplete understanding of the structure of lncRNAs has hindered molecular …
Characterizing and circumventing sequence restrictions for synthesis of circular RNA in vitro
Just as eukaryotic circular RNA (circRNA) is a product of intracellular backsplicing, custom
circRNA can be synthesized in vitro using a transcription template in which transposed halves …
circRNA can be synthesized in vitro using a transcription template in which transposed halves …
An evolved RNA recognition motif that suppresses HIV-1 Tat/TAR-dependent transcription
…, BD Blakeley, PH Chen, C Sherpa… - ACS chemical …, 2016 - ACS Publications
Potent and selective recognition and modulation of disease-relevant RNAs remain a daunting
challenge. We previously examined the utility of the U1A N-terminal RNA recognition motif …
challenge. We previously examined the utility of the U1A N-terminal RNA recognition motif …
Discovery of a branched peptide that recognizes the rev response element (RRE) RNA and blocks HIV-1 replication
We synthesized and screened a unique 46 656-member library composed of unnatural amino
acids that revealed several hits against RRE IIB RNA. Among the hit peptides identified, …
acids that revealed several hits against RRE IIB RNA. Among the hit peptides identified, …
Evolution of the HIV-1 rev response element during natural infection reveals nucleotide changes that correlate with altered structure and increased activity over time
The HIV-1 Rev response element (RRE) is a cis-acting RNA element characterized by multiple
stem-loops. Binding and multimerization of the HIV Rev protein on the RRE promote the …
stem-loops. Binding and multimerization of the HIV Rev protein on the RRE promote the …
[HTML][HTML] Structural fluidity of the human immunodeficiency virus rev response element
C Sherpa, SFJL Grice - Viruses, 2020 - mdpi.com
Nucleocytoplasmic transport of unspliced and partially spliced human immunodeficiency
virus (HIV) RNA is mediated in part by the Rev response element (RRE), a ~350 nt cis-acting …
virus (HIV) RNA is mediated in part by the Rev response element (RRE), a ~350 nt cis-acting …
Adeno-associated viral vector mediated expression of broadly-neutralizing antibodies against HIV-hitting a fast-moving target
C Sherpa, SFJ Le Grice - Current HIV Research, 2020 - ingentaconnect.com
The vast genetic variability of HIV has impeded efforts towards a cure for HIV. Lifelong
administration of combined antiretroviral therapy (cART) is highly effective against HIV and has …
administration of combined antiretroviral therapy (cART) is highly effective against HIV and has …
Molecular recognition of a branched peptide with HIV-1 Rev Response Element (RRE) RNA
Interaction of HIV-1 rev response element (RRE) RNA with its cognate protein, Rev, is
critical for HIV-1 replication. Understanding the mode of interaction between RRE RNA and …
critical for HIV-1 replication. Understanding the mode of interaction between RRE RNA and …